ETIOLOGY OF ARF Intrinsic Renal azotemia 4 Diseases Involving Large renal vessels Diseases of Glomeruli And microvasculature A Acute Tubule necrosis Diseases of the Tubulointerstitium
ETIOLOGY OF ARF Intrinsic Renal Azotemia ❖ Diseases Involving Large Renal Vessels ❖ Diseases of Glomeruli And Microvasculature ❖ Acute Tubule Necrosis ❖ Diseases of the Tubulointerstitium
急性肾小管坏死 Acute Tubule necrosis CAN)
急性肾小管坏死 Acute Tubule Necrosis （ATN）
ETOLOGYOF ATN Renal Ischemia (50%) ● Nephrotoxins(35%) Exogenous Endogenous
ETIOLOGY OF ATN ⚫ Renal Ischemia（50%） ⚫ Nrphrotoxins （35%） Exogenous Endogenous
PATHOPHYSIOLOGY OF ATN Intrarenal vasoconstriction ● Tubular Dysfunction
PATHOPHYSIOLOGY OF ATN ⚫ Intrarenal Vasoconstriction ⚫ Tubular Dysfunction
Role of Hemodynamic alterations in atn X Reduction in Total renal blood Flow Regional disturbance in Renal blood flow and oxygen Supply Edothelin(Et)/NO (EDNO) X Other endothelial vasoconstrctors X The Tubulo-glomerular Feed back
Role of Hemodynamic alterations in ATN ❖ Reduction in Total Renal Blood Flow Regional Disturbance in Renal Blood Flow and Oxygen Supply ❖ Edothelin (ET) / NO (EDNO) ❖ Other Endothelial Vasoconstrctors ❖ The Tubulo-glomerular Feed Back