Allergic rhinitis Lizi Qiu E.N.T department The second affiliated hospital Guangzhou Medical college
Allergic Rhinitis Lizi Qiu E.N.T department The second affiliated hospital Guangzhou Medical College
Background o Rhinitis is defined as inflammation of the nasal membranes and is characterized by a symptom complex that consists of any combination of the following: sneezing, nasal congestion nasal itching, and rhinorrhea. Allergic rhinitis is the most common cause of rhinitis
Background ⚫ Rhinitis is defined as inflammation of the nasal membranes and is characterized by a symptom complex that consists of any combination of the following: sneezing, nasal congestion, nasal itching, and rhinorrhea. Allergic rhinitis is the most common cause of rhinitis
Background o Total cost $5. 3 billion per year.(in America) o Morbidity 10%-40%(in China) o Classification Perennial allergic rhinitis Seasonal allergic rhinitis(pollinosis)
Background ⚫ Total cost $5.3 billion per year. (in America) ⚫ Morbidity 10%-40% ( in China) ⚫ Classification Perennial allergic rhinitis Seasonal allergic rhinitis (pollinosis)
Pathophysiology o Allergic reaction is an exaggerated or inappropriate immune reaction and causes damage to the host Type I immediate hypersensitivity reaction mediated by IgE antibodies which trigger the mast cells and basophils to release pharmacologically active agents
Pathophysiology ⚫ Allergic reaction is an exaggerated or inappropriate immune reaction and causes damage to the host ⚫ Type I immediate hypersensitivity reaction mediated by IgE antibodies, which trigger the mast cells and basophils to release pharmacologically active agents
Membrane-bound IgE L Histamine, leukotrienes, Acute Allergic Mast c Interleukin-5 Reaction Wheezy Interleukin-4 Urticaria Sneezing, rhinorrhea unctivitis Allergen Eosinophil IgE production Basic proteins, platelet-activating erleukin-4 Dendrite Th2 Chronic Allergic Further wheezing Histamine-releasing Mast cell lipids Sustained blockage of the nose Eczema MHC class Il T-cell receptor molecule Neurotrophins d