Allergic rhinitis变应性鼻炎 Lai he赖荷 E NT department The second affiliated hospital Guangzhou medical college 广医二院耳鼻咽喉教研室
Allergic Rhinitis变应性鼻炎 Lai he 赖荷 E.N.T department The second affiliated hospital Guangzhou medical college 广医二院耳鼻咽喉教研室
General information 1. Definition定义 Allergic rhinitis can be defined as a disease giving rise to two or three of the following symptoms: sneezing attacks serous hypersecretion(高分泌)and nasal blockage due to a swollen nasal mucosa 2 Morbidity(发病率)10%-40%
General information 1. Definition定义 Allergic rhinitis can be defined as a disease giving rise to two or three of the following symptoms: sneezing attacks serous hypersecretion（高分泌） and nasal blockage due to a swollen nasal mucosa. 2.Morbidity （发病率） 10%-40%
General information 3 Classification分类 Perennial allergic rhinits常年性变应性鼻炎 Seasonal allergic rhinitis季节性变应性鼻炎 pollinosis) 4 Atopic type特应型个体 It is a individual who brings the genes which have relation with allergic rhinitis(familial or hereditary nature 带有与变应性鼻炎发病有关的基因的个体
General information 3.Classification 分类 Perennial allergic rhinits 常年性变应性鼻炎 Seasonal allergic rhinitis 季节性变应性鼻炎 ( pollinosis) 4.Atopic type特应型个体 It is a individual who brings the genes which have relation with allergic rhinitis (familial or hereditary nature) 带有与变应性鼻炎发病有关的基因的个体
Pathophysiology病理生理 I type allergy一型变态反应 It is an inflammatory disorder characterized by an immunoglobulin E(gE)mediated hypersensitivity to allergens 由gE介导的机体对变应原超敏反应而引 起的炎症性损害
Pathophysiology病理生理 Ⅰtype allergy 一型变态反应 It is an inflammatory disorder characterized by an immunoglobulin E(IgE) mediated hypersensitivity to allergens 由IgE介导的机体对变应原超敏反应而引 起的炎症性损害
Pathophysiology病理生理 1. Sensitization致敏 contact Antigens 一 Respiratory mucosa呼吸道粘膜 activate CD4+ T Lymphocyte Th2 cell secrete Deliver signal IL4,L-5,IL-6,-10,-13( Mediators炎症介质) ↓ activate B cell Hemaendotheliocyte血管内皮细胞 ICAM-1( intercellular adhesion molecule1胞间粘附分子-1) produce attach Eosinophil嗜酸细胞 IgE Mast cell肥大细胞 go to nasal mucosa receptor on basophil嗜碱细胞 T lymphocyte淋巴细胞
Pathophysiology病理生理 1.Sensitization 致敏 contact Antigens Respiratory mucosa 呼吸道粘膜 activate CD4+ T Lymphocyte Th2 cell secrete Deliver signal IL-4,IL-5,IL-6,IL-10,IL-13 (Mediators炎症介质) activate B cell Hemaendotheliocyte 血管内皮细胞 ICAM-1(intercellular adhesion molecule-1细胞间粘附分子-1) produce attach Eosinophil嗜酸细胞 IgE Mast cell 肥大细胞 go to nasal mucosa receptor on basophil嗜碱细胞 T lymphocyte淋巴细胞