PG phospholipase A Lysophospholipid coo omh(②-mhph COo oH+ H3 Coo IGGy Prostaglandin Acetylated. Salicylate endoperoxide acetylsalicylate) inactivated OOH CH, CHa Other Thromboxanes CHa Coo
PG
K2 Fatty acid breakdown 1. Overview 2. Activation 3. Transport into mitochondria °4.阝- Oxidation pathway 5. Oxidation of unsaturated fatty acids 6. Oxidation of odd-chain fatty acids 7. Regulation 8. Energy yield 9. Ketone bodies
• 1. Overview • 2. Activation • 3. Transport into mitochondria • 4. β-Oxidation pathway • 5. Oxidation of unsaturated fatty acids • 6. Oxidation of odd-chain fatty acids • 7. Regulation • 8. Energy yield • 9. Ketone bodies K2. Fatty acid breakdown
Overview Fatty acid breakdown brings about the oxidation of long-chain fatty acids with the production of energy in the form of ATP Fatty acid breakdown include B-oxidation (fatty acid degrade into acety l CoA); citric acid cycle and oxidative phosphorylation ★
Overview • Fatty acid breakdown brings about the oxidation of long-chain fatty acids with the production of energy in the form of ATP. • Fatty acid breakdown include β-oxidation (fatty acid degrade into acetyl CoA); citric acid cycle and oxidative phosphorylation
Stages of fatty acid oxidation CHS cH oxidation CHe 8 Acetvi-CoA CHO CH CH Citre C CH? cH IcO. 重age3 NADE FADHO 2H++是Oa par-t (electron transfer) chain- △DP+上i A
Stages of fatty acid oxidation
Activation Fatty acid breakdown occurs in the cytosol of prokaryotes and in the mitochondrial matrix of eukaryotes The fatty acid is activated by forming a thioester link with coa before entering the mitochondria
Activation • Fatty acid breakdown occurs in the cytosol of prokaryotes and in the mitochondrial matrix of eukaryotes. • The fatty acid is activated by forming a thioester link with CoA before entering the mitochondria