Lipid Individual units are wedge-shaped Individual units are cavity cross-section of head cylindrical (cross-section greater than that of head equals that of side chain U of side chain (b) Outer face Phospholipid Fatty acyl Carbohydrate moiety tails(nonpolar of glycoprotein Peripheral protein Integral proteins Peripheral protein Inner face with covalent lipid anchor
Lipid
hormone Hormone bands 五exe The occupied 吧多里 = Actve Plc clea s phosphatidyl tokto4,占bis inositoL phosph在e(上)d IP binds to Ca-
hormone
Prostaglandins Prostaglandins前列腺素 and the other eicosanoids类二十烷酸( prostacyclins 前列环素, thromboxanes凝血恶烷and eukotrienes白三烯) are derived from arachidonate花生四烯酸. These compounds all act as local hormones
Prostaglandins • Prostaglandins 前列腺素 and the other eicosanoids 类二十烷酸 (prostacylins 前列环素, thromboxanes 凝血恶烷 and leukotrienes 白三烯) are derived from arachidonate 花生四烯酸. These compounds all act as local hormones
Arachidonic acid and some of its eicosanoid derivatives Membrane phospholipid CH-o-c CH A head group 0 0 0 0 C Leukotriene A, Prostaglandin E, 0 (PGEJ CHa
Arachidonic acid and some of its eicosanoid derivatives • Thromboxane A2
eicosanoid Arachidonate Prostaglandin synthase Prostaglandin H2 Leukotrienes Prostacyclin Other Thromboxanes prostaglandins Fig. 2. Biosynthetic relationship of the eicosanoids
eicosanoid