告构基因( Strucutre genes) Gene Encoded Function of Protein Protein gag P24, p7 Nucleocapsid p17 Matrix pol Reverse Transcribes RNA genome transcriptase into dnA Protease Cleaves precusor polypeptides Integrase Integrates viral DNA into host cell dna env gp120 Attachment to CD40 protein Fusi ith host cell
结构基因（Strucutre Genes） Gene Encoded Protein Function of Protein gag P24, p7 Nucleocapsid p17 Matrix pol Reverse transcriptase Transcribes RNA genome into DNA Protease Cleaves precusor polypeptides Integrase Integrates viral DNA into host cell DNA env gp120 Attachment to CD40 protein gp41 Fusion with host cell
调节基因( Regulatory Genes) vif viral infectivity factor tat transactivating protein vpu viral protein U rev regulator of virion protein e× pression nef negative regulatory factor
调节基因（Regulatory Genes） vif viral infectivity factor tat transactivating protein vpu viral protein U rev regulator of virion protein expression nef negative regulatory factor
Regulatory Genes Found in HIV That Are Required for Replication Gene Protein Protein Function tat Tat Activation of transcription of viral genes rev Rev Transport of late mRNA from nucleus to cytoplasm
Regulatory Genes Found in HIV That Are Required for Replication Gene Protein Protein Function tat Tat Activation of transcription of viral genes rev Rev Transport of late mRNA from nucleus to cytoplasm
Regulatory Genes Found in HIV That Are Not Required for Replication Genes Protel Function of protein nef Nef Decreases CD4 proteins and class I MHC proteins on surface of infected cells Important for pathogenesis by SIV vif Vif Stabilizes newly synthesized viral DNA and transports core through cytoplasm vpr Vpr Transports viral core from cytoplasm nto nucleus in nondividing cells vpu Enhances virion release from cell
Regulatory Genes Found in HIV That Are Not Required for Replication Genes Protei n Function of Protein nef Nef Decreases CD4 proteins and class I MHC proteins on surface of infected cells Important for pathogenesis by SIV vif Vif Stabilizes newly synthesized viral DNA and transports core through cytoplasm vpr Vpr Transports viral core from cytoplasm into nucleus in nondividing cells vpu Vpu Enhances virion release from cell
TM MA CA NC RNA genome RT