MPF activity Progesterone Fertilization G, arrest Meiosis I Meiosis Il First Second metaphase arrest embryonic embryonic mItosIs mitosis Time
MPF activity
MPF activity Metaphase High cyclin B High MPF activity Cyclin B Protein Prophase kinase subunit Inactive ATP ADP Active Proteasome Synthesis of cyclin B Late functions Late anaphase Interphase Low cyclin B Low MPF activity Teloph
MPF activity
Variations in the activities of specific CDKs during the cell cycle in animals G1 G 2 M G1 Cyclin B-CDKI :o日 Cyclin A-CDK2 Cyclin E-CDK2 Time
Variations in the activities of specific CDKs during the cell cycle in animals
Regulation of Cdk activity by phophorylation and proteolysis lation on Tyr ② Cyclin hosphorylation of Thr in T loop and CDK phosphorylates phosphatase, wh activates more CDK I ① P No cyclin CDK ig inactive ⑦ DBRP tn DBRP, activating molecules to cycli by ubiquitin 8) degraded leaving CDK inactive
Regulation of CDK activity by phophorylation and proteolysis
Activation of cyclin-dependent protein kinases( CDks)by clin and phophorylation CDK2 T ATP cyclin CDK2
Activation of cyclin-dependent protein kinases (CDKs) by cyclin and phophorylation CDK2 T loop ATP cyclin CDK2