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IFN-YKNOCKOUTANDCONTROLMICEINFECTEDWITH M.tuberculosis100?80e%6040GKO (-I-)WT (+/+)2020503040STDays p.i
IFN-γ KNOCKOUT AND CONTROL MICE INFECTED WITH M. tuberculosis Days p.i. Days p.i. % Survival % Survival GKO (-/-) GKO (-/-) WT (+/+) WT (+/+) 0 10 20 60 100 80 60 40 20 0 30 40 50
ISTBPATHOLOGYCAUSEDBYTNFa?InducesnecrosisintumorandparenchymalcellsMediates,inpart,endotoxinshockInducesiNOSandproductionofRNIinmice?
IS TB PATHOLOGY CAUSED BY TNFα? • Induces necrosis in tumor and parenchymal cells • Mediates, in part, endotoxin shock • Induces iNOS and production of RNI in mice
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SURVIVAL OF C57BL/6 MICE AN TNFR55-/- MICE INFECTED WITH M. tuberculosis 64670-6 Anti-TNFά IgG TNFp55R-/- Days Post Infection % S u rviv al % S u rviv al 0 20 60 80 100 80 60 40 20 0 40 100 120 140