V3:2CD1SSCCIBBROADMGH1811INSTITUTECanterfarComsutstianalS lstaprative BiolA Race Against ResistanceDeborah T.Hung,M.D.-Ph.D.Broad Institute of MiT and HarvardandDepartmentofMolecularBiologyCenterforComputational and Integrative BiologyMassachusettsGeneralHospitalandDepartment of Microbiologyand Molecular GeneticsHarvardMedicalSchool22October2008
A Race Against Resistance Deborah T. Hung, M.D.-Ph.D. Broad Institute of MIT and Harvard and Department of Molecular Biology Center for Computational and Integrative Biology Massachusetts General Hospital and Department of Microbiology and Molecular Genetics Harvard Medical School 22 October 2008
Theglobalproblem~56million deaths/yearworldwideOther14%InfectiousRespiratorydiseasesdisease27%6%Injuries10%Cancer13%Cardiovasculardisease30%worldwide
Deaths 2004, WHO Infectious diseases 27% Cardiovascular disease 30% Cancer 13% Injuries 10% Respiratory disease 6% Other 14% The global problem ~ 56 million deaths/year worldwide worldwide
Theglobalproblem~56milliondeaths/yearworldwideNutritional1%图Maternal2%OtherPerinatal14%Infectious6%RespiratorydiseasesInjuriesdisease27%11%Infectious6%diseasesInjuries45%10%CancerNoncommunic13%Cardiovascularabledisease35%30%worldwidedevelopingnations~1/3oftotaldeathsworldwide
Deaths 2004, WHO Infectious diseases 45% Noncommunic able 35% Injuries 11% Perinatal 6% Maternal 2% Nutritional 1% Deaths 2004, WHO Infectious diseases 27% Cardiovascular disease 30% Cancer 13% Injuries 10% Respiratory disease 6% Other 14% The global problem ~ 56 million deaths/year worldwide ~ 1/3 of total deaths worldwide worldwide developing nations
LeadinginfectiouskillersMillions of deaths, worldwide,all ages, 19983.5Over age five3.0Under age five2.52.32.2siasn2.01.51.51.11.00.90.5AIDS*AcuteDiarhoealTBMalariaMeasiesrespiratorydiseasesinfections(including"HVpestshTBhuuAdpneumoniaandSaucxWHQ 1989influenza)The majorityarecurable
Leading infectious killers The majority are curable
Targeting childrenHigher-incomecountry/regionBurtina FasoThe death30%United States5Cokimbe13%of a childEurope5Egypt32%Percentageofwomenaged15to49,hdonesa26%Middle-and lower-incomemarriedorpreviouslymarried,regionswho have hadat least one child dieKena49%Africa77Mt52%Eastern64Kamba26Mediterranean57SoutheastAsiaPaistan30Peru25%Pacificregion45LatinAmericaPiiippnes19%38andCaribbean45%Senegal38EasternEurope40%UnkedPrpubfoafTanzaniaChild deaths frominfectious diseases,Yemen2selected regions2000-2003(percentage)>51%ofdeathsinchildrenworldwide=infection
> 51% of deaths in children worldwide = infection Targeting children