3. Anatomically well-defined defect Defect: Excise complete epithelia and stroma Spontaneous healing: Full-thickness defect in conjunctiva heals by contraction and scar synthesis
3. Anatomically well-defined defect Defect: Excise complete epithelia and stroma. Spontaneous healing: Full-thickness defect in conjunctiva heals by contraction and scar synthesis
Conjunctiva wound model Conjunctiva Scaffold dRt Tenons capsule Sclera
Conjunctiva wound model Conjunctiva Tenon’s capsul e Sclera Sclera Scaffold D R T Sutures
4. Synthesis of conjunctival stroma, followed by re epithelialization Sequential synthesis (as for skin) Synthesize stroma using dermis regeneration template(RT) Epithelial tissue spontaneously synthesized over new stroma
4. Synthesis of conjunctival stroma, followed by reepithelialization Sequential synthesis (as for skin): Synthesize stroma using dermis regeneration template (DRT). Epithelial tissue spontaneously synthesized over new stroma
Effect of DRT on contraction kinetics of conjunctival defect. It is experimentally convenient to study contraction of the fornix a tissue attached to the conjunctiva ungrafted Ec 万 15 grafted with scaffold DRT 15 Days Hsu et al 2000
Effect of DRT on contraction kinetics of conjunctival defect. It is experimentally convenient to study contraction of the fornix, a tissue attached to the conjunctiva. ungrafted grafted with scaffold DRT 30 % Fornix Shortening 15 0 0 15 30 Days Hsu et al., 2000
14 days epithelialization ungrafted (red) of scar(blue) Image removed due to copyright considerations See Figure 6 in [Hsu 2000] epithelialization grafted with DRT (red) of incipient new dermis (blue)
14 days epithelialization (red) of scar (blue) ungrafted Image removed due to copyright considerations. See Figure 6 in [Hsu 2000] Image removed due to copyright considerations. See Figure 6 in [Hsu 2000] epithelialization (red) of incipient new dermis (blue) grafted with DRT