PathologyProtrudedtypeTheBorrmannclassificationType1systemdevelopedin1926;itremainsusefultodayforthedescriptionofendoscopicfindingsType2Thissystemdividesgastriccarcinomaintofivetypes,dependingonthelesion'smacroscopicappearanceType 3DepressedtypeOnetype,linitisplastica,describesadiffuselyinfiltratinglesioninvolvingtheentirestomach.Type4
Pathology The Borrmann classification system developed in 1926; it remains useful today for the description of endoscopic findings. This system divides gastric carcinoma into five types, depending on the lesion’s macroscopic appearance. One type, linitisplastica, describes a diffusely infiltrating lesion involving the entire stomach
PathologyDIFFUSEINTESTINALLaurenClassificationsystemseparatesgastricadenocarcinomaFamilialEnvironmentalintointestinalordiffusetypesGastric atrophy,intestinal metaplasiaBlood typeAbasedonhistology,withbothtypes havingdistinctpathology,Men>womenWomen>menepidemiology,andprognosis.Increasing incidence with ageYounger age groupGland formationPoorly differentiated, signetring cellsHematogenous spreadTransmural,lymphaticspreadMicrosatellite instabilityDecreased E-cadherinAPCgenemutationsp53,p16inactivationp53,p16inactivation
Pathology Lauren Classification system separates gastric adenocarcinoma into intestinal or diffuse types based on histology, with both types having distinct pathology, epidemiology, and prognosis
PathologyTypical adenocarcinoma with signet ringWell-circumscribedlesioninthecellsshownonclose-up.posteriorgastricbody
Pathology Typical adenocarcinoma with signet ring cells shown on close-up. Well-circumscribed lesion in the posterior gastric body