Salmonella gastroenteritis 1. Gram-negative bacillus does not ferment lactose motile 2. S typhoidal: infect human S nontyphoidal: infect both wide and domestic animal
Salmonella Gastroenteritis 1. Gram-negative bacillus, does not ferment lactose, motile. 2. S.typhoidal: infect human S.nontyphoidal: infect both wide and domestic animal 11
Salmonella 3. Attaches to intestinal and colonic cells, and injects proteins that stimulate internalization 4. Spreads to mesenteric nodes; Salmonella choleraesuis and S typhi often enter the bloodstream and cause bacteremia
Salmonella 3. Attaches to intestinal and colonic cells, and injects proteins that stimulate internalization. 4. Spreads to mesenteric nodes; Salmonella choleraesuis and S. typhi often enter the bloodstream, and cause bacteremia. 12
Salmonella 5. Salmonella organisms is acid-sensitive, with 104 to 108 s, required for infection Risk factors for disease include organisms a)antacid use b) prior antibiotics (reduces competition by normal flora) and c)depressed immune function (AIDS and transplant patients, sickle cell disease
Salmonella 5. Salmonella organisms is acid-sensitive, with 104 to 108 organisms required for infection. Risk factors for disease include a) antacid use, b) prior antibiotics (reduces competition by normal flora), and c) depressed immune function (AIDS and transplant patients, sickle cell disease). 13
Salmonella 6. Contracted from contaminated foods(more commonly in the summer months a)Chicken products(eggs, undercooked meat b) Contaminated processed foods(ice cream, unpasteurized goat cheese, whitefish, contaminated fruits and vegetables) c)Infected pet turtles, rodents, iguanas birds d) Contaminated water supply(S typhi
Salmonella 6. Contracted from contaminated foods (more commonly in the summer months): a) Chicken products (eggs, undercooked meat) b) Contaminated processed foods (ice cream, unpasteurized goat cheese, whitefish, contaminated fruits and vegetables) c) Infected pet turtles, rodents, iguanas, birds d) Contaminated water supply (S. typhi) 14
case1 A 52-year-old black woman with rheumatoid arthritis for 24 years was admitted to the hospital with complaints of fever and diarrhea for the preceding 24 hours One month earlier she had been hospitalized for neck surgery and received a 10-day course of a broad-spectrum antibiotic (ceftazidime Medications: asparin and large quantities of antacids Epidemioly: Her son had brought her an egg salad sandwich from Famous Deli, which they shared 16 hours before onset of the illness Her son also has severe diarrhea
case1 • A 52-year-old black woman with rheumatoid arthritis for 24 years was admitted to the hospital with complaints of fever and diarrhea for the preceding 24 hours. • One month earlier she had been hospitalized for neck surgery and received a 10-day course of a broad-spectrum antibiotic (ceftazidime). • Medications: asparin and large quantities of antacids. • Epidemioly: Her son had brought her an egg salad sandwich from Famous Deli, which they shared 16 hours before onset of the illness. Her son also has severe diarrhea. 15