Focus on chemicals of concern There must be a sharper focus on, and the establishment of properties for, those chemicals and chemical classes of great concern to human and environment Both industry and academia should focus their attention on those commercial chemicals and chemical classes that have the greatest potential for adverse effects. This involves not only an assessment of the toxicological properties per se, but also the extent of the potential exposure to human and th environment Factors such as production volume, use and physIco 四大学化学学院 2002年7月26日 26
四川大学化学学院 2002年7月26日 26 Focus on chemicals of concern ◼ There must be a sharper focus on, and the establishment of properties for, those chemicals and chemical classes of great concern to human and environment. ◼ Both industry and academia should focus their attention on those commercial chemicals and chemical classes that have the greatest potential for adverse effects. This involves not only an assessment of the toxicological properties per se, but also the extent of the potential exposure to human and th environment. ◼ Factors such as production volume, use and physico-
Mechanistic toxicological research Research in toxicology must shift its emphasis to mechanistic research, or basic understanding of how a specific chemical or chemical class exerts its toxicological effect on living organisms at the molecular level. It is only with the accumulation of substantial data and information of this nature that the existing principles and concepts of structure-activity relationship (SAr) can be developed further The sar of a chemical may involve one or more functiona groups, the parents compounds or a combination of functional groups and the parent chemical or chemical cla The elucidation of toxicological mechanisms on a chemicals specific or class specific basis and the systematic compilation of this data will provide the necessary foundation and guidance for the molecular manipulation by synthetic chemists to develop safer chemicals 四大学化学学院 2002年7月26日
四川大学化学学院 2002年7月26日 27 Mechanistic toxicological research ◼ Research in toxicology must shift its emphasis to mechanistic research, or basic understanding of how a specific chemical or chemical class exerts its toxicological effect on living organisms at the molecular level. ◼ It is only with the accumulation of substantial data and information of this nature that the existing principles and concepts of structure-activity relationship (SAR) can be developed further. ◼ The SAR of a chemical may involve one or more functional groups, the parents compounds or a combination of functional groups and the parent chemical or chemical class. ◼ The elucidation of toxicological mechanisms on a chemical specific or class specific basis and the systematic compilation of this data will provide the necessary foundation and guidance for the molecular manipulation by synthetic chemists to develop safer chemicals
Mechanistic toxicological research To stimulate interest and provide academia with the means to undertake more basic research in toxicology, the appropriate institutions must accept the concept and actively participate by making funds available in this specific area of research Without financial support for conduct of more basic mechanistic research. the opportunities for new, creative molecular structures that are both efficatious and sa will be severely limited 四大学化学学院 2002年7月26日
四川大学化学学院 2002年7月26日 28 Mechanistic toxicological research ◼ To stimulate interest and provide academia with the means to undertake more basic research in toxicology, the appropriate institutions must accept the concept and actively participate by making funds available in this specific area of research. ◼ Without financial support for conduct of more basic mechanistic research, the opportunities for new, creative molecular structures that are both efficatious and safe will be severely limited
Revision of chemical education The revision of the existing concepts and practices of chemical education at both undergraduate and graduate level is needed Separated mode of education traditionally Although thfere function of designing safer chemicals can be accomplished through multi-disciplinary collaboration among chemists, toxicologists, pharmacologists, bio chemists and others it is believed that individuals with a combined knowledge of chemical structure, industrial application and biological activity at the molecular level will perform more efficiently and effectively It is believed that this would be true even if such ane individual functioned as part of a multi-disciplinary team This is born out by experience with medicinal chemists and pesticide chemists and their effectiveness in developing new pharmaceuticals and pesticides 四大学化学学院 2002年7月26日
四川大学化学学院 2002年7月26日 29 Revision of chemical education ◼ The revision of the existing concepts and practices of chemical education at both undergraduate and graduate level is needed. ◼ Separated mode of education traditionally ◼ Although thfere function of designing safer chemicals can be accomplished through multi-disciplinary collaboration among chemists, toxicologists, pharmacologists, biochemists and others, it is believed that individuals with a combined knowledge of chemical structure, industrial application and biological activity at the molecular level will perform more efficiently and effectively. ◼ It is believed that this would be true even if such an individual functioned as part of a multi-disciplinary team. ◼ This is born out by experience with medicinal chemists and pesticide chemists and their effectiveness in developing new pharmaceuticals and pesticides
Revision of chemical education To provide adequate training of synthetic chemists interested in designing safer chemicals and destined for careers in both academia and industry, it is believed that new curricula should be developed to provide firm groundings in biochemistry, pharmacology and toxicology At the graduate level this may be best accomplished through joint appointments and multi disciplinary graduate committees comprised of the appropriate fields of study to oversee curricula graduate research efforts directly related toile ed chemistry/biology relationships involved in designing safer chemicals 四大学化学学院 2002年7月26日
四川大学化学学院 2002年7月26日 30 Revision of chemical education ◼ To provide adequate training of synthetic chemists interested in designing safer chemicals and destined for careers in both academia and industry, it is believed that new curricula should be developed to provide firm groundings in biochemistry, pharmacology and toxicology. ◼ At the graduate level this may be best accomplished through joint appointments and multidisciplinary graduate committees comprised of the appropriate fields of study to oversee curricula and graduate research efforts directly related to the chemistry/biology relationships involved in designing safer chemicals