Alternative MicroFabrication and Applications in Medicine and Biology Massachusetts Institute of Technology 6.152-Lecture 15 Fa|2003 These slides prepared by Dr. Hang Lu MIT BioMEMS. Fall 2003
Alternative MicroFabrication and Applications in Medicine and Biology Massachusetts Institute of Technology 6.152 - Lecture 15 Fall 2003 These slides prepared by Dr. Hang Lu MIT BioMEMS, Fall 2003
Outline of Today's Materials Intro Alternative materials and fabrication techniques Applications in biology and chemistry Applications in medicine A real MTL example of rapid prototyping MIT BioMEMs. Fall 2003
Outline of Today’s Materials • Intro • Alternative materials and fabrication techniques • Applications in biology and chemistry • Applications in medicine • A real MTL example of rapid prototyping MIT BioMEMS, Fall 2003
Micro Systems for Bio /Med Micro systems have characteristic length scale in the order of microns. Human hair width is-100 microns. The applications of these systems span Biological analysis Medical diagnosis Chemical analysis and synthesis Drug discovery Drug Delivery 重重 MIT BioMEMS. Fall 2003
Micro Systems for Bio / Med • Micro systems have characteristic length scale in the order of microns. (Human hair width is ~100 microns.) • The applications of these systems span – Biological analysis – Medical diagnosis – Chemical analysis and synthesis – Drug discovery – Drug Delivery – … MIT BioMEMS, Fall 2003
Advantages of Micro Systems Small length scale Laminar flow good and bad High surface-to-volume ratio Small thermal mass Close to some biological length scale Shorter processing time Less sample /reagent required Disposable Automation possible Parallel operation possible-high throughput Integration possible Whitesides(harvard U. Photo credit: Felice Frankel y MIT BioMEMS. Fall 2003
Immunoassay chip (Aclara) Advantages of Micro Systems • Small length scale • Laminar flow (good and bad) • High surface-to-volume ratio • Small thermal mass • Close to some biological length scale • Shorter processing time • Less sample / reagent required • Disposable • Automation possible • Parallel operation possible – high throughput • Integration possible Whitesides (Harvard U.); Photo credit: Felice Frankel MIT BioMEMS, Fall 2003
Alternative materials Materials requirement for bioMEMS is different from that for mems Desired properties of bioMEMS materials Biocompatible Chemically modifiable Easy to fabricate Economic Soft and compliable Smart If not Si and glass, what then? Polymers( e.g. PDMS, PMMA) are good materials especially for biological applications MIT BioMEMS. Fall 2003
Alternative Materials • Materials requirement for bioMEMS is different from that for MEMS. • Desired properties of bioMEMS materials – Biocompatible – Chemically modifiable – Easy to fabricate – Economic – Soft and compliable – Smart • If not Si and glass, what then? • Polymers (e.g. PDMS, PMMA) are good materials especially for biological applications. MIT BioMEMS, Fall 2003