Chapter 15 Microbial Mechanisms of Pathogenicity
Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings B.E Pruitt & Jane J. Stein Chapter 15 Microbial Mechanisms of Pathogenicity
Microbial Mechanisms of Pathogenicity 。Pathogenicity The ability to cause disease ·Virulence The extent of pathogenicity
Microbial Mechanisms of Pathogenicity • Pathogenicity The ability to cause disease • Virulence The extent of pathogenicity
Portals of Entry ·Mucous membranes 。Skin ·Parenteral route
• Mucous membranes • Skin • Parenteral route Portals of Entry
Numbers of Invading Microbes ID50:Infectious dose for 50%of the test population 。 LD50:Lethal dose (of a toxin)for 50%of the test population
• ID50: Infectious dose for 50% of the test population • LD50: Lethal dose (of a toxin) for 50% of the test population Numbers of Invading Microbes
Bacillus anthracis Portal of entry 1D50 Skin 10-50 endospores Inhalation 10,000-20,000 endospores Ingestion 250,000-1,000,000 endospores
Bacillus anthracis Portal of entry ID50 Skin 10-50 endospores Inhalation 10,000-20,000 endospores Ingestion 250,000-1,000,000 endospores