Chapter 21,part B Microbial Diseases of the Skin and Eyes
Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings B.E Pruitt & Jane J. Stein Chapter 21, part B Microbial Diseases of the Skin and Eyes
Poxviruses ·Smallpox(Variola ·Smallpox virus (Orthopox virus) 。Variola major has 20%mortality 。Variola minor has <1%mortality ·Monkeypox 。Prevention by smallpox vaccination Figure 21.9
• Smallpox (Variola) • Smallpox virus (Orthopox virus) • Variola major has 20% mortality • Variola minor has <1% mortality • Monkeypox • Prevention by smallpox vaccination Poxviruses Figure 21.9
Herpesviruses (a)Initial infection:chickenpox(varicella) Nerve cell in dorsal Latent root ganglion viral DNA Spinal cord Varicella-zoster virus (Human herpes virus 3) Viruses move up peripheral nerve 。Transmitted by the respiratory route Causes pus-filled vesicles Virus may remain latent in dorsal root ganglia Figure 21.10a
• Varicella-zoster virus (Human herpes virus 3) • Transmitted by the respiratory route • Causes pus-filled vesicles • Virus may remain latent in dorsal root ganglia Herpesviruses Figure 21.10a
Shingles (b)Recurrence of infection:shingles(herpes zoster Activation of viral DNA in nerve cell Viruses Spinal cord Viruses move down Reactivation of latent peripheral nerve HHV-3 releases viruses that move along peripheral nerves to skin. Figure 21.10b
• Reactivation of latent HHV-3 releases viruses that move along peripheral nerves to skin. Shingles Figure 21.10b
Herpes simplex 1 and Herpes simplex 2 Human herpes virus 1 and HHV-2 。 Cold sores or fever blisters (vesicles on lips) Herpes gladiatorum (vesicles on skin) Herpes whitlow(vesicles on fingers) Herpes encephalitis (HHV-2 has up to a 70%fatality rate) HHV-1 can remain latent in trigeminal nerve ganglia HHV-2 can remain latent in sacral nerve ganglia Acyclovir may lessen symptoms
• Human herpes virus 1 and HHV-2 • Cold sores or fever blisters (vesicles on lips) • Herpes gladiatorum (vesicles on skin) • Herpes whitlow (vesicles on fingers) • Herpes encephalitis (HHV-2 has up to a 70% fatality rate) • HHV-1 can remain latent in trigeminal nerve ganglia • HHV-2 can remain latent in sacral nerve ganglia • Acyclovir may lessen symptoms Herpes simplex 1 and Herpes simplex 2