>Kinetic classification ( Classified according to etiology and pathogenesis) Decreased erythropoiesis I Proliferation and differentiation abnormalities fsc HSC: AA. Fanconis anemia MDs Erythrocytic progenitors Pure red cell aplasia, Anemias caused by kidney failure and endocrine disorders
Kinetic classification (Classified according to etiology and pathogenesis) 一 、Decreased erythropoiesis 1 Proliferation and differentiation abnormalities of SC HSC: AA, Fanconis anemia, MDS Erythrocytic progenitors : Pure red cell aplasia, Anemias caused by kidney failure and endocrine disorders
2 Marrow infiltration leukemias carcinoma multiple myeloma myelofibrosis Malignant histocytosis
2 Marrow infiltration leukemias carcinoma multiple myeloma myelofibrosis Malignant histocytosis
3 Production and maturation blockages of differentiating cells DNA Synthesis blockage: Vit b12, falic acid difficiencies,嘌呤和嘧啶 metabolic defects->Megaloblastic anema Hb synthesis blockage Heme production defect IDA Heptoglobin production defect Thalassemias
3 Production and maturation blockages of differentiating cells DNA synthesis blockage : Vit B12, falic acid difficiencies, 嘌呤和嘧啶 metabolic defects→Megaloblastic anemia Hb synthesis blockage : Heme production defect : IDA Heptoglobin production defect : Thalassemias
4 Unknown reason or several echanisms Sideroblastic anemia Chronic disease anemias(chronic inflammation, infections,尿毒症 Hepatic disorders, neoplasm connective tissue disease. endocrine disorders)
4 Unknown reason or several mechanisms Sideroblastic anemia Chronic disease anemias (chronic inflummation, infections, 尿毒症, Hepatic disorders, neoplasm, connective tissue disease, endocrine disorders)
二、 Accelerated destruction of red cells 1) Endogenous (intra-erythrocyte defects) 1. Membrane defects of erythrocytes: Hereditary Hereditary spherocytosis (HS) Hereditas elliplocytosis (he) Acquired: PNH 2. Enzyme defects Glucose--6--Phosphate Dehydrogenase G6PD)deficiency Pyruvate kinase deficiency 3.Abnormal haptoglobin synthesis. Sickle cell anemia, Hemoglobinopathies Thalassemias
二、Accelerated destruction of red cells 1）Endogenous (intra-erythrocyte defects) 1.Membrane defects of erythrocytes : Hereditary :Hereditary spherocytosis (HS) Hereditasy elliplocytosis (HE) Acquired : PNH 2.Enzyme defects Glucose--6--Phosphate Dehydrogenase (G6PD) deficiency Pyruvate kinase deficiency 3.Abnormal haptogllbin synthesis : Sickle cell anemia, Hemoglobinopathies Thalassemias