上游充通大￥ Treatment of cancer 后 Shanghai Jiao Tong University There are three main approaches to treating established cancer:Surgery, Radiation therapy,Chemotherapy Breast cancer Surgery Radiation Chemotherapy Chemotherapy of cancer,as compared with that of bacterial disease, presents a difficult problem.In biochemical terms,cancer cells and normal cells are so similar in most respects that it is more difficult to find general,exploitable,biochemical differences between them
Shanghai Jiao Tong University Treatment of cancer There are three main approaches to treating established cancer: Surgery, Radiation therapy, Chemotherapy Chemotherapy of cancer, as compared with that of bacterial disease, presents a difficult problem. In biochemical terms, cancer cells and normal cells are so similar in most respects that it is more difficult to find general, exploitable, biochemical differences between them. Breast cancer Surgery Radiation Chemotherapy
上商充通大学 Shanghai Jiao Tong University 1.Surgery 2.Radiotherapy 3.Chemotherapy 4.Endocrine therapy 5.Immunotherapy 6.Biological therapy
Shanghai Jiao Tong University 1. Surgery 2. Radiotherapy 3. Chemotherapy 4. Endocrine therapy 5. Immunotherapy 6. Biological therapy
上充通大学 后 Shanghai Jiao Tong University Anticancer drug development in vitro assays for measuring drug sensitivity of a battery of human tumor cells in vivo,a few well-characterized transplantable animal tumor systems preclinical toxicological and limited pharmacological studies in animals phase I clinical trials ■■■
Shanghai Jiao Tong Universit A y nticancer drug development in vitro assays for measuring drug sensitivity of a battery of human tumor cells in vivo, a few well-characterized transplantable animal tumor systems preclinical toxicological and limited pharmacological studies in animals phase I clinical trials …
PURINE SYNTHESIS PYRIMIDINE SYNTHESIS PENTOSTATIN 5-FLUOROURACIL 上 inhibits adenosine inhibits DTMP synthesis 后 deaminase RIBONUCLEOTIDES BLEOMYCINS 6-MERCAPTOPURINE 6-TIOGUANINE damage DNA and prevent repair inhibit purine synthesis DEOXYRIBONUCLEOTIDES ALKYLATING AGENTS, inhibit nucleotide MITOMYCIN,CISPLATIN interconversions cross-link DNA METHOTREXATE MNMNM CAMPOTHECINS inhibits purine synthesis DOXORUBICIN inhibits DTMP synthesis ETOPOSIDE DNA AMSACRINE CYTARABINE inhibit topoisomerase ll inhibits DNA polymerase inhibit RNA synthesis inhibits RNA function DACTINOMYCIN CRISANTASPASE intercalates in DNA deaminates asparagine inhibits topoisomerase ll inhibits protein synthesis RNA (transfer.messenger.ribosomal) inhibits RNA synthesis VINCA ALKALOIDS TAXANES PROTEINS inhibit function of microtubules ENZYMES(etc.) MICROTUBULES Elsevier.Rang et al:Pharmacology 6e-www.studentconsult.com Summary of the main sites of action of cytotoxic agents.For some groups of drugs,only one or two examples are given
Shanghai Jiao Tong University Summary of the main sites of action of cytotoxic agents. For some groups of drugs, only one or two examples are given
上游充通大学 Resistance to anticancer drugs Shanghai Jiao Tong University primary resistance Acquired resistance multidrug resistance,associated with increased expression of a normal gene (the MDR1 gene)for a cell surface glycoprotein (P-glycoprotein)involved in drug efflux
Shanghai Jiao Tong Unive R rsity esistance to anticancer drugs primary resistance Acquired resistance multidrug resistance, associated with increased expression of a normal gene (the MDR1 gene) for a cell surface glycoprotein (P-glycoprotein) involved in drug efflux