Tumours of the larynx
Tumours of the larynx
Tumours of larynxBenign :Papilloma(85%)ChondromaMalignant:Sguamous cell carcinoma(85%)Carcinomain situVerrucous carcinomaundifferenciated carcinomaadenocarcinomaadenoid cysticcarcinomasarcoma
Tumours of larynx ◼ Benign : Papilloma (85%) Chondroma ◼ Malignant : Squamous cell carcinoma (85%) Carcinoma in situ Verrucous carcinoma undifferenciated carcinoma adenocarcinoma adenoid cystic carcinoma sarcoma
SCClarynxEpidemiologyGeographical variation?Themostcommoncancerof H&N1%ofallmalignanciesMale:female=5:1SeventhdecadeRisk factorsSmokingGeographicAlcoholSocial classVRadiationUrban
SCC larynx Epidemiology ◼ Geographical variation ◼ ? The most common cancer of H & N ◼ 1% of all malignancies ◼ Male : female = 5 : 1 ◼ Seventh decade Risk factors ◼ Geographic Smoking ◼ Social class V Alcohol ◼ Urban Radiation
Aetiology:oUnknownHyoid bonn,AryopigtottieoreatetcorrufoidUoporabove factorspartThyroyoidmembrareTubercle otQuadrargufarepighotimkeratosis/membraneSacculeof larynxMiddieVesttbular foidleukoplakiapartThyraid cartlageLaryngeat wentricioCompartmentsVocal foaldoflarynxLowerThyroirytenaispartCricovocalmemtraneChicoidcartilage1.Supraglottisventricle,FVCarytenoidFig.36.9Coronalsection throughthe larynxand thecanlalend ofthetracheawtacineepiglottisaryepiglotticfoldlemricularVallecula2. Glottic -TVC, antHocolEpiglon& postcordcommissureCuniformPglaniccartilogeL3.SubglotticCorniculatePyriformconilogefossaInferarytenoidarea
◼ Aetiology : Unknown above factors keratosis / leukoplakia ◼ Compartments of larynx 1. Supraglottis – ventricle, FVC arytenoid, epiglottis, aryepiglottic fold 2. Glottic –TVC, ant & post commissure 3. Subglottic -
Clinicalfeatures of SCC larynxPrimary tumour:Glottic carcinoma is thecommonest inlarynxcontinuos progressive hoarseness >3weeksin>40ymaledyspnoea,dysphagia,painSecondary deposits:Neckswelling,chestsymptoms(cough,irritation)General effects of the tumour :anorexia,cachexia,foetor
Clinical features of SCC larynx ◼ Primary tumour :Glottic carcinoma is the commonest in larynx continuos progressive hoarseness > 3 weeks in >40y male dyspnoea, dysphagia, pain ◼ Secondary deposits : Neck swelling, chest symptoms (cough,irritation) ◼ General effects of the tumour : anorexia, cachexia, foetor