(a) () ( 0=C1 oo 0c-09 oe CH: CH: CH CH: CH: CH: CH CH: CH CH. CH CH: CH: CH: H H. H CH cis CH: H CH: CH: CH, CH. HO CH: CH, trans CH. CH: CH CH: CH, CH: CH H Stearate Oleate Linolenate unsatturated fatty acids
unsatturated fatty acids cis trans
Fatty acid degradation fatty acid transport in blood fatty acid uptake into cells activation of fatty acids in the cytosol translocation of fatty acids into the mitochondrion ·Knoop's experiments b Oxiation thio-klastic cleavage by thiokinase degradation of uneven fatty acids degradation of unsaturated fatty acids
• fatty acid transport in blood • fatty acid uptake into cells • activation of fatty acids in the cytosol • translocation of fatty acids into the mitochondrion • Knoop‘s experiments • b Oxiation • thio-klastic cleavage by thiokinase • degradation of uneven fatty acids • degradation of unsaturated fatty acids Fatty acid degradation
Lipoproteine (Chylomikronen H,O und LDL) TG+ Chol-E FATP Mcoo CoA-SH TG+ Mitochondrium ChoL-E Acyl-CoA Synthetase Acyl-CoA c00 +Glycerol Acyl-CoA Carnitin Carnitin Endothel Acyl-Carnitin TG=Triacylglycerine Acyl-Carnitin Chol-E=Cholesterol-Ester +CoA-SH LPL=Lipoprotein-Lipase FATP =fatty acid transport protein
Fatty acid activation CHa-(CH2)a-C by ATP and formation of acetyl-CoenzymeA 0H20 =02P01 CHa-(CH2) CHa-(CH2)-C-S-CoA Acyl-CoA AMP
Fatty acid activation by ATP and formation of acetyl-CoenzymeA
Lipoproteine (Chylomikronen H,0 und LDL) TG+ Chol-E FATP Mcoo +CoA-SH TG+ Albumin Mitochondrium Chol-E Acyl-CoA Synthetase ∧Λc00 Acyl-CoA +Glycerol Acyl-CoA Carnitin Endothel Acyl-Carnitin TG =Triacylglycerine Acyl-Carnitin Chol-E=Cholesterol-Ester +CoA-SH LPL Lipoprotein-Lipase FATP =fatty acid transport protein