Glomerular nephritisX8.400显示正常的肾小球基底膜（BM)：内皮细胞（En），足细胞（P）及足突（FP)Normal glomeruli在肾小球基底膜外侧见一园锥状电子致密物（H）一驼峰
Glomerular nephritis Normal glomeruli
PathologyImmunofluorescence免疫荧光IgGandC3ingranularpatternalongGBMsIgG和C3沿GBM成颗粒状沉积IF ×400 IgG沿肾小球毛细血管壁呈不连续的颗粒样荧光肾小球系膜区也可见团块状沉积
Pathology Immunofluorescence免疫荧光 IgG and C3 in granular pattern along GBMs IgG和C3沿GBM 成颗粒状沉积
Clinical ManifestationsPoststreptococcal glomerulonephritis ismostcommonin children,rare before3yr.post-streptpharyngitis（咽炎）orpyoderma（脓皮病）and otherinfections.Prodromalperiod前驱期Pharyngitis--- 1-2 wk,Pyoderma---2-3wks
Clinical Manifestations Poststreptococcal glomerulonephritis is most common in children, rare before 3 yr. post-strept pharyngitis(咽炎) or pyoderma(脓皮 病) and other infections. Prodromal period前驱期 Pharyngitis- 1-2 wk; Pyoderma- 2-3 wks
Clinical ManifestationsTypicalCases典型病例Hematuria/Proteinuria·Edema（salt and water retention水钠潴留）· Oliguria (GFR I)·Hypertension >7ys 130/90mmHg<7ys120/80mmHg
Clinical Manifestations Typical Cases典型病例 • Hematuria / Proteinuria • Edema (salt and water retention水钠潴留) • Oliguria (GFR ) • Hyp e rtension >7ys 130/90mmHg <7ys 120/80mmHg
Edema
Edema