Pathophysiology Decrease of Glomerular filtration rate(GFR)Azotemia ---Bun↑, Cr I, UA↑OliguriaEdema, hypertension, hyperemia: Damaged in Glomerular basementmembrane(GBM)Proteinuria蛋白尿，hematuria血尿，cylindruria管型尿
Pathophysiology • Decrease of Glomerular filtration rate (GFR) Azotemia - Bun↑, Cr ↑, UA↑ Oliguria Edema, hypertension, hyperemia • Damaged in Glomerular b asement memb r ane (GBM) Proteinuria蛋白尿, hematuria血尿, cylindruria管型尿
APSGN病理生理肾小球炎症病变内皮细胞肿胀、系膜细胞增生肾小球基底膜（GBM）破坏毛细血管管腔狭窄蛋白尿血尿肾小球滤过面积管型尿氮质血症肾小球滤过率(GFR)球管失衡少尿、无尿水肿高血压钠、水潴留，血容量扩张循环充血
肾小球炎症病变 内皮细胞肿胀、系膜细胞增生 毛细血管管腔狭窄 肾小球滤过面积 肾小球滤过率 (GFR) 球管失衡 钠、水潴留，血容量扩张 肾小球基底膜(GBM) 破坏 蛋白尿 血 尿 管型尿 氮质血症 少尿、无尿 水肿 高血压 循环充血 APSGN病理生理
PathologyLight MicroscopeEnlarged,hypercellular glomeruliwithendothelial and mesangial cellproliferation.弥漫性丶渗出性丶增生性毛细血管内增生性肾炎
Pathology Light Microscope Enlarged, hypercellular glomeruli with endothelial and mesangial cell proliferation. 弥漫性、渗出性、增生性 毛细血管内增生性肾炎
Glomerular nephritisPAS X400正常肾小球Normal glomeruliE×400肾小球体积增大，细胞数增多，可见大量单核细胞和中性粒细胞浸润，肾小球毛细血管腔狭窄或闭塞
Normal glomeruli Glomerular nephritis
PathologyElectron MicroscopeIgG and C3 in granular patternalongGBMs.Discrete分散，subepithelial上皮下“hump-like”deposits.驼峰样沉积电子致密物（IgG,C3)在上皮下呈“驼峰样”沉积
Pathology Electron Microscope IgG and C3 in granular pattern along GBMs. Discrete分散, subepithelial上皮下 “hump- like” deposits. 驼峰样沉积. 电子致密物（IgG, C3)在上皮下呈“驼峰样”沉积