8.5 Post-translational membrane insertion depends on leader sequences 的37对 cepto游 t Dm22 2&receptor Tom5: 6 om40= channel Figure 8.13 TOM proteins form receptor complex(es) that are needed for translocation across the mitochondrial outer membrane 消当
Figure 8.13 TOM proteins form receptor complex(es) that are needed for translocation across the mitochondrial outer membrane. 8.5 Post-translational membrane insertion depends on leader sequences
8.5 Post-translational membrane insertion depends on leader sequences Tim17-23= channel?: Intermembrane space Tim44 Hsp70 Matrix MGE Figure 8.14 Tim proteins form the complex for translocation across the mitochondrial inner membrane 消当
Figure 8.14 Tim proteins form the complex for translocation across the mitochondrial inner membrane. 8.5 Post-translational membrane insertion depends on leader sequences
TOM Cytosol 8.5 Post-translational membrane insertion depends on leader sequences Figure 8.15 Tim9-10 im9.: B 13 takes proteins from Inter TOM to either TIM membrane space complex, and Tim& 13 takes proteins to Tim22-54 m723am24 消当
Figure 8.15 Tim9-10 takes proteins from TOM to either TIM complex, and Tim8- 13 takes proteins to Tim22-54. 8.5 Post-translational membrane insertion depends on leader sequences
TOM Cytosol 8.5 Post-translational 000 membrane insertion depends on leader sequences Protein passes rectly from TOM to Tim9-10 land then to TIM Intermem brane space Figure 8.16A translocating protein may be transferred directly from TOM to Tim22-54 消当 Tim 22-54= channe Matrⅸ
Figure 8.16 A translocating protein may be transferred directly from TOM to Tim22-54. 8.5 Post-translational membrane insertion depends on leader sequences
● Signal for 8.6A hierarchy of outer membrane sequences determines location within TOM receptor organelles TIM receptor SrU Matutum nner mem bran Intemem brane space Figure 8.17 Mitochondria have receptors e Outer membrane for protein transport in the outer and Signal for interrmem brane space nner membranes. Recognition at the outer membrane may lead to transport through both receptors into the matrix. where the leader is cleaved. If it has a membrane-targeting signal, it may be re exported MAn 消当
Figure 8.17 Mitochondria have receptors for protein transport in the outer and inner membranes. Recognition at the outer membrane may lead to transport through both receptors into the matrix, where the leader is cleaved. If it has a membrane-targeting signal, it may be reexported. 8.6 A hierarchy of sequences determines location within organelles