Chapter 25 Protein trafficking 莘大
Chapter 25 Protein trafficking
25.1 Introduction 25.2 Oligosaccharides are added to proteins in the er and golgi 25.3 The Golgi stacks are polarized 25.4 Coated vesicles transport both exported and imported proteins 25.5 Different types of coated vesicles exist in each pathway 25.6 Cisternal progression occurs more slowly than vesicle movement 25.7 Vesicles can bud and fuse with membranes 25.8 SNARES control targeting 25.9 The synapse is a model system for exocytosis 25.10 Protein localization depends on specific signals 25 11 ER proteins are retrieved from the golgi 25. 12 Brefeldin A reveals retrograde transport 25. 13 Receptors recycle via endocytosis 25. 14 Internalization signals are short and contain tyrosine 消当
25.1 Introduction 25.2 Oligosaccharides are added to proteins in the ER and Golgi 25.3 The Golgi stacks are polarized 25.4 Coated vesicles transport both exported and imported proteins 25.5 Different types of coated vesicles exist in each pathway 25.6 Cisternal progression occurs more slowly than vesicle movement 25.7 Vesicles can bud and fuse with membranes 25.8 SNAREs control targeting 25.9 The synapse is a model system for exocytosis 25.10 Protein localization depends on specific signals 25.11 ER proteins are retrieved from the Golgi 25.12 Brefeldin A reveals retrograde transport 25.13 Receptors recycle via endocytosis 25.14 Internalization signals are short and contain tyrosine
25.1Introduction Sorting signal is a motif in a protein (either a short sequence of amino acids or a covalent modification) that is required for it to be incorporated into vesicles that carry it to a specific destination 消当
Sorting signal is a motif in a protein (either a short sequence of amino acids or a covalent modification) that is required for it to be incorporated into vesicles that carry it to a specific destination. 25.1 Introduction
25.1Introduction Figure 25.1 Proteins that enter the endoplasmic reticulum are Secreted proteins membrane transported to the golgi and towards the plasma membrane Gotai transact prote ins to plasma membrane Specific signals cause proteins trans Golgi t to be returned from the golgi ns occur to the eR, to be retained in the rom ch fo tai ns bosom es Golgi, to be retained in the plasma membrane or to be ransport to golgi prot eins retum to transported to endosomes and Proteins enter E uring synthesi transported between the plasma/oawvrg oiyrcosyation lysosomes. Proteins may be Endoplasmic reticulum385> membrane and endosomes 消当
Figure 25.1 Proteins that enter the endoplasmic reticulum are transported to the Golgi and towards the plasma membrane. Specific signals cause proteins to be returned from the Golgi to the ER, to be retained in the Golgi, to be retained in the plasma membrane, or to be transported to endosomes and lysosomes. Proteins may be transported between the plasma membrane and endosomes. 25.1 Introduction
25.1Introduction Vesicle fusion CYTOSOL Figure 25.2 Vesicles are onor com partment sicle contacts released when they bud from CYTOSoL' target membrane a donor compartment and are surrounded by coat proteins(left). During fusion, Coat is rem oved the coated vesicle binds to a Vesda buds from mem brane target compartment, IS SV2 Vesicle fuses with uncoated. and fuses with the target mem brane target membrane, releasing Veside is released its contents(right) 消当
Figure 25.2 Vesicles are released when they bud from a donor compartment and are surrounded by coat proteins (left). During fusion, the coated vesicle binds to a target compartment, is uncoated, and fuses with the target membrane, releasing its contents (right). 25.1 Introduction