Theiindirect-actingagents produce their primarytheaction of AchE,whicheffectsbyinhibitinghydrolyzes acetylcholine to choline and acetic acid.Byinhibiting AchE,the indirect-acting drugs increase theconcentration of acetylcholine,the excess acetycholinein turn stimulates cholinoceptorsthey are also called cholinesterase-inhibiting drugs
The indirect-acting agents produce their primary effects by inhibiting the action of AchE, which hydrolyzes acetylcholine to choline and acetic acid. By inhibiting AchE, the indirect-acting drugs increase the concentration of acetylcholine, the excess acetycholine in turn stimulates cholinoceptors they are also called cholinesterase-inhibiting drugs
A.Basic pharmacology of the direct-actingcholinoceptorA.The classification of cholinoceptoragonistmuscarinic receptors stimulants: pilocarpinenicotinic receptors stimulants:nicotinemuscarinic and nicotinic receptors stimulants:acetylcholine
A.The classification of cholinoceptor agonist muscarinic receptors stimulants: pilocarpine nicotinic receptors stimulants: nicotine muscarinic and nicotinic receptors stimulants: acetylcholine A. Basic pharmacology of the direct-acting cholinoceptor
Pharmacodvnamicsl:mechanismofactioncholinoceptor stimulants directly activate cholinoceptors.(muscarinicornicotinicreceptors,orbothreceptors)2:Organsystemeffect:Organ system effect of muscarinic receptors stimulants:Eye-a:Miosisrpupillary constrictor muscles (sphincter muscle of pupil):MRpupillary dilator muscles:aiR
Pharmacodynamics 1:mechanism of action cholinoceptor stimulants directly activate cholinoceptors, (muscarinic or nicotinic receptors, or both receptors) 2: Organ system effect: Organ system effect of muscarinic receptors stimulants: Eyea: Miosis pupillary constrictor muscles (sphincter muscle of pupil)：MR pupillary dilator muscles：a1R