Pathogenesis(Cont's) 2. Effects of Hypoxic-Ischemic Insults on Energy Metabolism(能力代谢) (1) Brain glucose√ (2)Lactate production T (3)ATP↓ (4)Energy failure (5)Neuronal death
Pathogenesis (Cont’s) 2. Effects of Hypoxic-Ischemic Insults on Energy Metabolism（能力代谢） (1) Brain glucose (2) Lactate production (3) ATP (4) Energy failure (5) Neuronal death
Pathogenesis(Cont's) 3 Role of free radicals(自由基) (1) Perioxidation(过氧化) of membrane phospholipids 2)Damage to DNA (3) Activation of proapoptotic(促凋亡) genes
Pathogenesis (Cont’s) 3. Role of Free Radicals (自由基) (1) Perioxidation (过氧化) of membrane phospholipids (2) Damage to DNA (3) Activation of proapoptotic (促凋亡) genes
Pathogenesis(Cont's) 4. Calcium Reflux(钙内流) (1) Activate phospholipases(磷脂酶) (2) Activate proteases(蛋白酶) (3) Activate nucleases(核酸酶) (4)T neurotransmitter release (5)钙内流,导致细胞死亡
Pathogenesis (Cont’s) 4. Calcium Reflux（钙内流） (1) Activate phospholipases (磷脂酶) (2) Activate proteases (蛋白酶) (3) Activate nucleases (核酸酶) (4) neurotransmitter release (5) 钙内流，导致细胞死亡
Pathogenesis(Cont's) 5. Neurotoxicity of Excitatory Amino Acids 兴奋性氨基酸) (1)Nat entry: with H2o cell swelling and lysis (2) Cat entry: Cat-mediated events to cell death
Pathogenesis (Cont’s) 5. Neurotoxicity of Excitatory Amino Acids (兴奋性氨基酸) (1) Na+ entry: with H2O cell swelling and lysis (2) Ca+ entry: Ca+ -mediated events to cell death
Pathogenesis(Cont's) 6. Delayed Cell Death(迟发性神经元死亡) (1) Cell death: Necrosis(坏死) and Apoptosis(凋亡) (2) Necrosis: occurs in minutes (3) Apoptosis: delayed cell death occurs over hours or days, or months
Pathogenesis (Cont’s) 6. Delayed Cell Death (迟发性神经元死亡) (1) Cell death: Necrosis (坏死) and Apoptosis (凋亡) (2) Necrosis：occurs in minutes (3) Apoptosis: delayed cell death occurs over hours or days， or months