2氨(NH3)的同化 ■氦的同化有两条途径: 1)谷氨酸脱氢酶(GDH)途径 ■2)谷酰胺合成酶((GS)和谷氨酸合成 酶与氨基转移酶( GOGAT))
2.氨(NH3 )的同化 ◼ 氨的同化有两条途径： ◼ 1）谷氨酸脱氢酶（GDH）途径 ◼ 2）谷酰胺合成酶（（GS）和谷氨酸合成 酶与氨基转移酶（GOGAT）)
Medium Cytoplasm glutamate supply d eylopame tomoe game in protet ond guAmote dep. troraomnases (GDH 1x NH, transmembrane diffusion NH GOGAT torne dep amat blomass (GS N wopt w myoplasmic gu puaamne in potent glutamine
Biochemistry 2/e-Garrett Grisham Garrett Grisham: Blachemlstry, 2/c Ca)NHE+a Ketoglutarate NADPH CDI Glutamate NADP+H,O cb) Glutamate+ NH ATP GLutamine ADP+:P SUM: 2 NHf t a Ketoglutarate t NADI'TI t ATP:" Glutamine t NADP ADP+ h+ I2o Saunders college Publishing Copyright e 1999 by Harcourt Brace &e Company
Biochemistry 2/e-Garrett Grisham Garrett Grisham: Blachemlstry, 2fe NADH (yeast, N. crassa) NAD NADPH (E coh)or -KG -1 CIn 2 Glu - NADPh ox H++2 reduced ferredoxin (plants) 2 oxidized ferredoxin CHO c 对 H NH ct-KG Glu Giu Copyright e 1999 by Harcourt Brace &e Company 谷氨酸合成酶与氨基转移酶( GOGAT)的作用过程
◼ 谷氨酸合成酶与氨基转移酶（GOGAT）的作用过程
coo scm一-C=o H2N一c—co HN coo- 【xal Aspartate Ammonium assimilation into amino coo acids HAN coo- AD的 dehyde aNDRE GDH NHA coo NH: CH? ⊙MADP N一C-coo Re*gInter次 GAslini ATP