5. Bacterial virulence factors Y Adherence factors: pili capsule: K antigen Vi antigen endotoxin Y Exotoxin( ST, LT, SLT, shiga toxin (÷ art of the outer portion of the cell berated when the bacteria die and the cell wall breaks apart
5. Bacterial Virulence Factors Adherence factors: pili capsule: K antigen Vi antigen endotoxin Exotoxin (ST, LT, SLT, shiga toxin )
√ Escherichia coli part of the normal flora diarrhea E. coli urinary tract infection WHY? Meningitis HOW?
Escherichia coli E. coli part of the normal flora diarrhea urinary tract infection Sepsis Meningitis WHY? HOW? E. coli WHY? HOW? E. coli
Case 21-vear old woman presented to the student health service of the university with a 2-day history of increasing urinary frequency with urgency and dysuria. Her urine had been pink or bloody for about 12 hours. She had no history of prior urinary tract infection (UTD. The patient had recently become sexually active and was using a diaphragm and spermicide
Case 21-year old woman presented to the student health service of the university with a 2-day history of increasing urinary frequency with urgency and dysuria. Her urine had been pink or bloody for about 12 hours. She had no history of prior urinary tract infection(UTI). The patient had recently become sexually active and was using a diaphragm and spermicide
Clinical features On physical examination, the only abnormal finding was mild tenderness to deep palpation in the suprapubiC lumbar emblica inba regon on area
Clinical Features … On physical examination, the only abnormal finding was mild tenderness to deep palpation in the suprapubic area
Laboratory Findings cab tests showed a slightly elevated white blood cell count of 13,000/ul; 66%o were PMNs,.Culture yielded more than 105 colony-forming units CFU/ml)of E coli(diagnostic of a urinary tract infection). Antimicrobial susceptibility tests were not done Treatment The patient was cured by 3 days of oral sulfamethoxazole-trimethoprim treatment
Laboratory Findings Lab tests showed a slightly elevated white blood cell count of 13,000/ul; 66% were PMNs,…. Culture yielded more than 105 colony-forming units (CFU/ml) of E.coli (diagnostic of a urinary tract infection). Antimicrobial susceptibility tests were not done. Treatment The patient was cured by 3 days of oral sulfamethoxazole-trimethoprim treatment