Eventually, when all of the antigen has been removed and none remains to stimulate b cells the antibody response will reach its peak and the concentration of antibody in the circulation will begin to decrease as a result of the normal rate of catabolism of the antibody
Eventually, when all of the antigen has been removed and none remains to stimulate B cells, the antibody response will reach its peak and the concentration of antibody in the circulation will begin to decrease as a result of the normal rate of catabolism of the antibody
At the time antigen is reintroduced more antigen specific B cells exist in the individual compared with the period before primary introduction of antigen. Moreover, these cells have differentiated to more responsive memory B cells
At the time antigen is reintroduced, more antigen specific B cells exist in the individual compared with the period before primary introduction of antigen. Moreover, these cells have differentiated to more responsive memory B cells
免疫记忆 Immunologic memory Ant-白喉 antibody Ant-白喉 antibody against白喉 白喉 vaccine—( D E 白喉 Bm cell 白喉 Bm cell
免疫记忆 Immunologic memory A B 白 喉vaccine D E Anti-白 喉antibody 白 喉B m cell Anti-白 喉antibody against白 喉 白 喉 B m cell
Primary and secondary humoral response (初次与再次体液免疫应答) 初次免疫 再次免疫 100000 初次应答 再次应答 抗原特异性血清抗体滴度 10000 1000 G 100 M 10 天数
Primary and Secondary Humoral Response (初次与再次体液免疫应答) 初次应答 再次应答 初次免疫 再次免疫 天 数 0 7 14 21 28 35 42 100000 10000 1000 100 10 1 0 抗 原 特 异 性 血 清 抗 体 滴 度 （Log ） IgG IgM
Specificity and memory in immune responses Antigen A Antigen a+ Antigen B Anti-A Anti-B Secondary anti-A response E Primary anti-A Primary anti-B response response 2 4 6 8 10 12 Weeks