Th2→细胞因子 CD40L CD4 B e→米 laM L-52 CD40 lL-4,6,2 B IFN →Yg IL-5 B 1GF(P→》gA -4→→YlE Mo B (m记忆B细胞 活化 增殖 分化 B细胞应答活化过程示意图
匚阻止病原体入侵 溶解细胞或细菌 联合调理作用 00101010 FcR CR 中和作用 活化补体 Ig特异性结合抗原 结合Fc受体 通过胎盘 态 FcR ADCC 调理作用 被动免疫 免疫球蛋白的功能
Humoral immunity Neutralization Cytokines Helper YY Antigen Opsonization and phagocytosis CD40 B cel Fc receptor CD40L Complement activation
2 1 3 4 5 Humoral immunity
2. Primary and memory responses When introduced into an individual who has not previously encountered the antigen, a primary immune response will develop within 4-5 days This response results initially in the production of IgM and then lgg or other antibody isotypes(同种 型抗体) directed toward the antigen, and has a duration(延续时间) and antibody isotype profile which depends on thethe quantity of antigen introduced and its mode of entry
When introduced into an individual who has not previously encountered the antigen , a primary immune response will develop within 4-5 days . This response results initially in the production of IgM and then IgG or other antibody isotypes(同种 型抗体) directed toward the antigen, and has a duration（延续时间）and antibody isotype profile which depends on the the quantity of antigen introduced and its mode of entry. 2. Primary and memory responses
The antibody produced reacts with remaining antigen, forming complexes and/or precipitates which are eliminated by phagocytes. Antibody is continually made by plasma cells during their short life span (3-4 days). If enough antigen is introduced initially, there could be restimulation of antigen specific B cells, subsequent development of more plasma cells and thus increased production of antibody
The antibody produced reacts with remaining antigen, forming complexes and/or precipitates which are eliminated by phagocytes. Antibody is continually made by plasma cells during their short life span (3-4 days). If enough antigen is introduced initially, there could be restimulation of antigen specific B cells, subsequent development of more plasma cells and thus increased production of antibody