BIOCHEMISTRYANDMOLECULARBIOLOGY3.Structure of glycosphingolipidA.Neutral glycosphingolipidsThe simplest neutral glycosphingolipids are the cerebrosidesB.Acidic glycosphingolipidsThe negative charge is provided by N-acetylneuraminic acidingangliosidesC.SulfatideSulfoglycosphingolipids( sulfatides) are found predominantlyinnervous tissue.Department of Biochemistry and Molecular Biology,Medicine School
Department of Biochemistry and Molecular Biology, Medicine School BIOCHEMISTRY AND MOLECULAR BIOLOGY A. Neutral glycosphingolipids The simplest neutral glycosphingolipids are the cerebrosides. B. Acidic glycosphingolipids The negative charge is provided by N-acetylneuraminic acid in gangliosides. C. Sulfatide Sulfoglycosphingolipids( sulfatides) are found predominantly in nervous tissue. 3. Structure of glycosphingolipid
ARBIOLOGYO-GlycosidicbondCHOHHHHOC-C-C-C-CH2OH1HNHOHOHHH-AWNAAAOECIHOHGalactoseCeramide(polarnead)(hydrophoblcta)Figure17.14Stnucture ofa neutral glyco-sphingoipidgalactccerebrosideisafattyacidhydrocarbonchain).veparunent ui Diucermsury anu iviuiecular Diuugy, iviedicine School
Department of Biochemistry and Molecular Biology, Medicine School BIOCHEMISTRY AND MOLECULAR BIOLOGY
CERAMIDEAULARBIOLOGYN-AcetviEactoamn-舌舌--SH工1GIUCOOHSHOHalectcseAAN-Acetyineuramlinlcacid(NANA)Figure17.15MedicineSchoolStructure of the ganglioside Gm2-
Department of Biochemistry and Molecular Biology, Medicine School BIOCHEMISTRY AND MOLECULAR BIOLOGY