Innate Immunity 口 FUNCTIONS 日 COMPONENTS u Innate immunity recognition u The influence on adaptive immunity
❑ FUNCTIONS ❑ COMPONENTS ❑ Innate immunity recognition ❑ The influence on adaptive immunity Innate Immunity
OVERVIEW The first line of defense against infection O An evolutionarily older defense strategy, found in al classes of plants and animals u preexist infection or exposure to foreign antigen u respond immediately after recognition of microbes O Respond in essentially the same way to repeated infection
OVERVIEW The first line of defense against infection ❑ An evolutionarily older defense strategy, found in all classes of plants and animals ❑ Preexist infection or exposure to foreign antigen ❑ Respond immediately after recognition of microbes ❑ Respond in essentially the same way to repeated infection
FUNCTIONS a Initial response to microbes to prevent infection with elimination of danger u Innate components also important in adaptive immunity u stimulates adaptive responses
❑ Initial response to microbes to prevent infection with elimination of danger ❑ Innate components also important in adaptive immunity ❑ Stimulates adaptive responses FUNCTIONS
Components of innate immune system Com ponents Principal Functions Epithe lial barriers Epithelial layers Prevent microbial entry Defensins Microbial killing intraepithelial Microbial killing lymphocytes Circulating effector cells Neutrophils Early phagocytosis and killing of microbes Macrophages Efficient phagocytosis and killing of microbes, secretion of cytokines that stimulate inflammation NK cells Lysis of infected cells, activation of macrophages Circulating effector proteins Complement Killing of microbes, opsonization of microbes, activation of leukocytes Mannose-binding lectin Opsonization of microbes, activation of complement(lectin (collectin) pathway) C-reactive protein Opsonization of microbes, activation of complement (pentraxin) Cytokines
Components of innate immune system Components Principal Functions Epithelial barriers Epithelial layers Prevent microbial entry Defensins Microbial killing Intraepithelial lymphocytes Microbial killing Circulating effector cells Neutrophils Early phagocytosis and killing of microbes Macrophages Efficient phagocytosis and killing of microbes, secretion of cytokines that stimulate inflammation NK cells Lysis of infected cells, activation of macrophages Circulating effector proteins Complement Killing of microbes, opsonization of microbes, activation of leukocytes Mannose-binding lectin (collectin) Opsonization of microbes, activation of complement (lectin pathway) C-reactive protein (pentraxin) Opsonization of microbes, activation of complement Cytokines
Epithelial barriers Physical barrier to infection Peptide Killing of microbesantibiotics by locally produced 叠→ antibiotics ⊙0 Intraepithelial Killing of microbes lymphocyte and infected cells by intraepithelial lymphocytes
Epithelial barriers