溶血性贫血 Hemolytic Anemia 山医血科 陈勤春
溶血性贫血 Hemolytic Anemia 华山医院血液科 陈勤奋
HEMOLYTIC ANEMIA (reduced RBC life span) Anemia of increased destruction ORNormochrom1c. normochromic anemla SHOrtened rBc survival CRReticulocytosis--Response to increased rbc destruction INCreased indirect bilirubin INcreased LDh
HEMOLYTIC ANEMIA (reduced RBC life span) ❖Anemia of increased destruction Normochromic, normochromic anemia Shortened RBC survival Reticulocytosis--Response to increased RBC destruction Increased indirect bilirubin Increased LDH
Mechanisms and causes INTRACORPUSCULAR HEMOLYSIS MEMbrane abnormalities mETabolic abnormalities hEMoglobinopathies EXTRACORPUSCULAR HEMOLYSIS NONimmune aR⊥ mmune
Mechanisms and Causes ❖INTRACORPUSCULAR HEMOLYSIS Membrane Abnormalities Metabolic Abnormalities Hemoglobinopathies ❖EXTRACORPUSCULAR HEMOLYSIS Nonimmune Immune
Membrane Defects Microskeletal defects cOHereditary spherocytosis g Increased sensitivity to complement paRoxysmal nocturnal hemoglobinuria
Membrane Defects ❖Microskeletal defects Hereditary spherocytosis ❖Increased sensitivity to complement Paroxysmal nocturnal hemoglobinuria
Enzymopathies .Glucose 6-Phosphate Dehydrogenase Deficiency o Pyruvate Kinase Deficiency
Enzymopathies ❖Glucose 6-Phosphate Dehydrogenase Deficiency ❖Pyruvate Kinase Deficiency