Stability Vitamin a is sensitive to ultraviolet or oxidation by the air So the compound should be stored in an aluminium container or vitamin e oil Vitamin a is not stable to acid and dehydration of vitamin a results in a dehydrate of vitamin a that is only 0. 4% potency of vitamin a
Stability • Vitamin A is sensitive to ultraviolet or oxidation by the air. So the compound should be stored in an aluminium container or vitamin E oil. • Vitamin A is not stable to acid and dehydration of vitamin A results in a dehydrate of vitamin A that is only 0.4% potency of vitamin A
Metabolism Vitamin a acetate is hydrolyzed by enzymes into vitamin a and further is oxidized to retinal and retinoic acid. Finally the conjugates of retinoic acid with glycuronic acid is excreted in bile or urine OH [O] ●
Metabolism • Vitamin A acetate is hydrolyzed by enzymes into vitamin A and further is oxidized to retinal and retinoic acid. Finally the conjugates of retinoic acid with glycuronic acid is excreted in bile or urine
Vitamin A analogs Vitamin a acid: it mainly influences skeleta growth and metabolism of epithelial tissue. It has better effect on prevention and cure of canner The compound is a choice drug for treatment of acute promyelocytic leukemia(APL) CH CH3 OH
Vitamin A analogs • Vitamin A acid: it mainly influences skeletal growth and metabolism of epithelial tissue. It has better effect on prevention and cure of canner. • The compound is a choice drug for treatment of acute promyelocytic leukemia (APL). H3C CH3 CH3 O CH3 CH3 OH
Vitamin d In 1922. vitamin d was found in fish liver oil In 1930, vitamin D,(ergocalciferol) was isolated In 1932, vitamin D cholecalciferol) was isolated Only difference between two vitamins is that there are a methyl group and a double bond on side chain of vitamin D2
Vitamin D • In 1922, vitamin D wasfound in fish liver oil. • In 1930, vitamin D2 (ergocalciferol) wasisolated. • In 1932, vitamin D3 (cholecalciferol) wasisolated. • Only difference between two vitamins is that there are a methyl group and a double bond on side chain of vitamin D2
Vitamin D3 (3B,5Z,7E)9, 10-Seco-cholesta-5, 7,10(19 )-trien-3B-ol There is a conjugated triene system in the structure in which there are a hydroxy group at C-3 on A ring, a methenyl group at C-10
Vitamin D3 • (3β,5Z,7E)-9,10-Seco-cholesta-5,7,10(19)-trien-3β- ol • There is a conjugated triene system in the structure in which there are a hydroxy group at C-3 on A ring, a methenyl group at C-10. HO H