Emphasis 1. Chemcially structural feature, physico-chemical property, stability 2. Biological effect adverse effects biotransformation etc 3. Structure-activity relationship, drug targets in living bodies as well as mode of action
Emphasis • 1. Chemcially structural feature, physico-chemical property, stability. • 2.Biological effect, adverse effects, biotransformation etc. • 3. Structure-activity relationship, drug targets in living bodies as well as mode of action
The important role of drugs in human society Drugs have irrevocably changed the fabric of society by improving both the individual quality of life and life expectancy Some examples are shown as follows 9
The important role of drugs in human society • Drugs have irrevocably changed the fabric of society by improving both the individual quality of life and life expectancy. • Some examples are shown as follows:
1. Bacterial and virus infections: polio smallpox, tuberculosis and related diseases have, to a very major extent, become minor public health concerns 2. An increase in life expectancy resulting from drug therapy has also led to a shift in population demographics toward a more healthy, elderly population 3. Drug regimens for birth control have improved individual life choices and the quality of life
• 1. Bacterial and virus infections: polio, smallpox, tuberculosis and related diseases have, to a very major extent, become minor public health concerns. • 2. An increase in life expectancy resulting from drug therapy has also led to a shift in population demographics toward a more healthy, elderly population. • 3. Drug regimens for birth control have improved individual life choices and the quality of life
4. HIv protease and reverse transcriptase inhibitors for the treatment of hiv infections have changed a disease with a fatal prognosis to a potentially chronic one 5. Cancer is also being viewed as a potentially chronic. rather than fatal disease with newer non cytotoxic approaches Notes: H/, Human immunodeficiency virus
• 4. HIV protease and reverse transcriptase inhibitors for the treatment of HIV infections have changed a disease with a fatal prognosis to a potentially chronic one. • 5. Cancer is also being viewed as a potentially chronic, rather than fatal disease with newer, noncytotoxic approaches. • Notes: HIV, Human immunodeficiency virus
Section 1 Origins of Medicinal Chemistry 1. Early investigations of natural products 1.1. In the so-called pre-scientific era Natural products having a history as folk remedies were in use. Fore examples, opium belladonna, cinchona bark, etc. Many drugs originally used as folk remedies, nowadays have been abandoned
Section 1 Origins of Medicinal Chemistry 1. Early investigations of natural products • 1.1.In the so-called pre-scientific era • Natural products having a history as folk remedies were in use. Fore examples, opium, belladonna, cinchona bark, etc. Many drugs originally used as folk remedies, nowadays, have been abandoned