The GFR was originally determined by injecting inulin into the plasma. Since inulin is not reabsorbed by the kidney after glomerular filtration,its rate of excretion is directly proportional to the rate of filtration of water and solutes across the glomerular filter
• The GFR was originally determined by injecting inulin into the plasma. Since inulin is not reabsorbed by the kidney after glomerular filtration, its rate of excretion is directly proportional to the rate of filtration of water and solutes across the glomerular filter
In clinical practice however, creatinine clearance is used to measure GFR.Creatinine is an endogenous molecule,synthesized in the body,which is freely filtered by the glomerulus(but also secreted by the renal tubules in very small amounts)
• In clinical practice however, creatinine clearance is used to measure GFR. Creatinine is an endogenous molecule, synthesized in the body, which is freely filtered by the glomerulus (but also secreted by the renal tubules in very small amounts)
oCreatinine clearance is therefore a close approximation of the GFR.The GFR is typically recorded in milliliters per minute ml/min). CCr=Ucr(mg/dl)XV(ml/min)/Pcr(mg/dl)
• Creatinine clearance is therefore a close approximation of the GFR. The GFR is typically recorded in milliliters per minute (ml/min). CCr=Ucr(mg/dl) ×V(ml/min) ／ Pcr(mg/dl)
The Cockcroft-Gault formula for estimating CrCl should be used routinely as a simple means to provide a reliable approximation of residual renal function in all patients with CKD. The formulas are as follows: CrCl(male)=([140-age]X weight in kg)/(serum creatinine X 72) CrCl (female)=CrCl (male)X 0.85 Body weight in kg,Plasma Creatnine in mg/dL .The normal range of GFR for males and females is: Males:97 to 137 ml/min. Females:88 to 128 ml/min
– The Cockcroft-Gault formula for estimating CrCl should be used routinely as a simple means to provide a reliable approximation of residual renal function in all patients with CKD. The formulas are as follows: • CrCl (male) = ([140-age] X weight in kg)/(serum creatinine X 72) • CrCl (female) = CrCl (male) X 0.85 • Body weight in kg,Plasma Creatnine in mg/dL • The normal range of GFR for males and females is: – Males: 97 to 137 ml/min. – Females: 88 to 128 ml/min
-Alternatively,the Modification of Diet in Renal Disease (MDRD)Study equation could be used to calculate GFR.This equation does not require a patient's weight (Levey,1999
– Alternatively, the Modification of Diet in Renal Disease (MDRD) Study equation could be used to calculate GFR. This equation does not require a patient's weight (Levey, 1999