125胺的反应 Reactions of amines
Organic Chemistry Organic Chemistry Xiamen Xiamen University University 12.5 胺的反应 Reactions of Amines
Acylation Primary and secondary (but not tertiary) amines can be acylated by reaction with acid chlorides or acid anhydrides to yield amides. NH 3 RCNH 2 O Pyridine R'NH, R-C-CI R-C-NHR' RCNR 2
Organic Chemistry Organic Chemistry Xiamen Xiamen University University Acylation Primary and secondary (but not tertiary) amines can be acylated by reaction with acid chlorides or acid anhydrides to yield amides. NH 3 R'NH 2 R' 2NH R C Cl O + Py r idi n e R C NH 2 O R C NHR' O R C NR' 2 O
9 Hinsberg Reaction g. If a sulfonyl chloride, RSO2Cl, is used as g the acylating agent, a sulfonamide is produced R-S--CI R--S-NHR Sulfonyl chloride Sulfonamide
Organic Chemistry Organic Chemistry Xiamen Xiamen University University Hinsberg Reaction If a sulfonyl chloride, RSO 2Cl , is used as the acylating agent, a sulfonamide is produced. R S Cl O O Sul fo nyl chlorid e R S NHR O O Sulfo namid e
RNH Ph--S-NHR O Pyridine R2NH Ph-S-CI Ph--S-NR RoN Ph-S一NR ①D ⑨D Ph-S-oh +rN H2O
Organic Chemistry Organic Chemistry Xiamen Xiamen University University R 3 N RNH 2 R 2NH + Py r idi n e Ph S NHR O Ph S NR 2 O S Cl O O Ph O O Ph S NR 3 O O H 2 O S OH + R 3 N O O Ph
Quaternary Ammonium Compounds g- Quaternary ammonium salt 25 CHsn chal C2H53N CH3 I ether Triethylmethylammonium iodide a Quaternary ammonium hydroxide Ag2o a( C2H5)3N CH3 I (C2H53N CH3 OH Triethylmethy lammonium hydroxide
Organic Chemistry Organic Chemistry Xiamen Xiamen University University Quaternary Ammonium Compounds Quaternary ammonium salt (C 2 H 5 ) 3N + CH 3 I 25 ether (C 2 H 5 ) 3 N +CH 3 I - Triethylm ethylam m onium io d i d e Quaternary ammonium hydroxide (C 2 H 5 ) 3 N +CH 3 I - Ag 2 O (C 2 H 5 ) 3 N +CH 3 OH - Tri e thylm e thylam m onium hyd r o x i d e