123胺的制备 Preparation of Amines
Organic Chemistry Organic Chemistry Xiamen Xiamen University University 12.3 胺的制备 Preparation of Amines
Alkylation of ammonia or amines NaoH E Nh2 +rX 一RNH3X RNH 2 + Naoh RNH2+RX—-R2NH2x RONH ●● Naoh R2NH+R-X RBNH X R3N ①D ●● R3N+RⅩ RAN X ⑨D RI>RBr>RCl1°RX>2°RX
Organic Chemistry Organic Chemistry Xiamen Xiamen University University Alkylation of ammonia or amines NH 3 + R X RNH 3 X NaOH RNH 2 RNH 2 + R X R 2NH 2 X NaOH R 2NH R 2NH + R X R 3NH X NaOH R 3 N R 3 N + R X R 4N X RI > RBr > RCl 1 R X > 2 R X
a Gabriel Synthesis KOH NH R一X Etoh NK O h or oh COH RNHo t HO CO,H N-R ①D H2NNH2 NH RNH, NH ⑨D Etoh O
Organic Chemistry Organic Chemistry Xiamen Xiamen University University Gabriel Synthesis NH O O KOH EtOH N K O O R X N O O R H + or O H H 2 O H 2NNH 2 EtOH CO 2 H CO 2 H RNH 2 + RNH 2 + NH NH O O
Preparing Amines from Alcohols AlO ROH Nh RNH+ron+ron+ho △,压力 NH3 ROH TsCl ROTS—-RNH2+TsO
Organic Chemistry Organic Chemistry Xiamen Xiamen University University Preparing Amines from Alcohols ROH + Ts C l RNH 2 + Ts O ROH + NH 3 , 压力 RNH 2 + R 2NH + R 3 N + H 2 O ROTs NH 3 Al 2 O 3
Ph Ph nK TSC OH H OTS CH Ph Ph h2nnH2 H HoN H Etoh O CH CH3
Organic Chemistry Organic Chemistry Xiamen Xiamen University University Ph H OH CH 3 TsC l Py. Ph H OTs CH 3 N K O O N O O Ph H CH 3 H 2NNH 2 EtOH H 2 N Ph H CH 3