(CH3)4N CI (CH3 CH2 CH2 CH2)4N Br U Tetramethylammonium chloride Tetrabutylammonium bromide 四甲基氯化铵 四丁基溴化铵 (氯化四甲基铵) CH Ch cochochonch2 br CH Acetylcholine bromide 溴化乙酰胆碱
Organic Chemistry Organic Chemistry Xiamen Xiamen University University (C H 3 ) 4 N+ Cl - (C H 3CH 2CH 2CH 2 ) 4 N+ Br - T etramethylam m o nium chlorid e Tetrabutylam m onium b r o mid e CH 3CO 2CH 2CH 2NCH 3 Br CH 3 CH 3 A cetylcholine b r o mid e (氯化四甲基铵 ) 四甲基氯化铵 四丁基溴化铵 溴化乙酰胆碱
Hofmann elimination CHaI CH3(CH2)5 NH2 CH3(CH2)5N(CH3)3 I (excess) Ag,o △ CH3(CH25N(CH3)3 OH 9 CH3CH2CH2CH2CH=CH2+(CH3)3N
Organic Chemistry Organic Chemistry Xiamen Xiamen University University Hofmann Elimination Hofmann Elimination CH 3(CH2 ) 5NH2 CH 3 I (excess) CH 3(CH2 ) 5 N(CH3 ) 3 I Ag 2 O CH 3(CH2 ) 5 N(CH3 ) 3 OH CH 3CH2CH2CH2CH CH2 + ( CH 3 ) 3 N
HO E2 C-C C=C、+N(CH3)3 N(CH3)3 FN(CH3)3 HO CHrCH, CH,CH-CH D CH3CH, CH, CHCH 94:6 CH3 CHO CHFCHCH3 ⑨D
Organic Chemistry Organic Chemistry Xiamen Xiamen University University C C H N(CH 3 ) 3 HO E2 C C + N(CH 3 ) 3 CH 3CH 2CH 2CHCH 3 CH 3CH 2CH 2CH CH 2 N(CH 3 ) 3 HO CH 3CH 2CH CHCH 3 94 : 6