Two types of intracellular signaling proteins that act as Molecular Switches SIGNAL OFF SIGNAL OFF IN IN GDP ATP protein protein GDP GTP GTP kinase phosphatase GTP binding hydrolysis ADP ON ON GTP SIGNAL SIGNAL OUT OUT (A)SIGNALING BY PHOSPHORYLATION (B) SIGNALING BY GTP-BINDING This document is produced by trial version of Print2Flash.Visit www.print2flash.com for more information
The regulation of a monomeric GTPase INACTIVE GAP(GTPase- MONOMERIC GTPase activating proteins) GEFs (Guanine GEF nucleotide-exchange GDP factors) GAP GDP GTP GTP ACTIVE MONOMERIC GTPase This document is produced by trial version of Print2Flash.Visit www.print2flash.com for more information
胞外 信号分子 1↓ 3.Cell signaling systems 细胞膜 细胞 表面受体 2 胞内 信号分子 3↓ 信号 级联反应 4 靶蛋白 代谢酶 基因调控 细胞 蛋白 骨架蛋白 影响 激活或阻遏 改变细胞 细胞代谢 基因表达 形状和运动 This document is produced by trial version of Print2Flash.Visit www.print2flash.com for more information
Three types of intracellular signaling complexes (1) PREFORMED SIGNALING COMPLEX ON A SCAFFOLD PROTEIN inactive receptor signal molecule -activated receptor CYTOSOL plasma membrane scaffold 26 protein inactive activated intracellular intracellular signaling proteins signaling proteins downstream signals This document is produced by trial version of Print2Flash.Visit www.print2flash.com for more information
Three types of intracellular signaling complexes (2) ASSEMBLY OF SIGNALING COMPLEX ON AN ACTIVATED RECEPTOR inactive receptor signal molecule activated intracellular signaling proteins activated receptor inactive intracellular signaling proteins 3 downstream signals This document is produced by trial version of Print2Flash.Visit www.print2flash.com for more information