Three types of intracellular signaling complexes (3) ASSEMBLY OF SIGNALING COMPLEX ON PHOSPHOINOSITIDE DOCKING SITES specific phospholipid signal molecule inactive molecules activated receptor receptor (phosphoinositides) hyperphosphorylated phosphoinositides activated intracellular downstream signals inactive intracellular signaling proteins signaling proteins This document is produced by trial version of Print2Flash.Visit www.print2flash.com for more information
A specific signaling complex formed using modular interaction domains extracellular signal molecule phosphoinositide plasma docking sites membrane CYTOSOL PH PH PTB SH3 activated receptor SH2 Grb2(adaptor protein) SH3 IRS1(docking protein) scaffold protein This document is produced by trial version of Print2Flash.Visit www.print2flash.com for more information
Signaling integration plasma membrane B ATP ATP ADP ADP DOWNSTREAM SIGNALS This document is produced by trial version of Print2Flash.Visit www.print2flash.com for more information
Section 2.Cell signaling mediated by intracellular receptor ligand-binding domain transcription-activating domain DNA-binding domain COOH inhibitory INACTIVE RECEPTOR proteins This document is produced by trial version of Print2Flash.Visit www.print2flash.com for more information
coactivator proteins ligand DNA receptor-binding transcription of target genes element ACTIVE RECEPTOR This document is produced by trial version of Print2Flash.Visit www.print2flash.com for more information