Extracellular Matrix (ECM) Collagen Fibronectin Laminin Proteoglycan D 6d86的 This document is produced by trial version of Print2Flash.Visit www.print2flash.com for more information
ECM Concept:An orderly network outside cells,consisting of secreted protein and polysaccharide by cells. Function:Adhesion,support,regulate the microenvironment of cells,signaling transition,cell proliferation,differentiation, survival,and death. Types:Glycosaminoglycan proteoglycans,collagen elastin, fibronectin laminin,and the plant cell wall. This document is produced by trial version of Print2Flash.Visit www.print2flash.com for more information
Contents Extracellular cell matrix 1 Components of ECM Basal lamina 3 Interaction between ECM and cells This document is produced by trial version of Print2Flash.Visit www.print2flash.com for more information
Components of ECM ECM Structure Gel-like matrix Fiber network Molecules GAG PG Collagen elastin fibronectin laminin This document is produced by trial version of Print2Flash.Visit www.print2flash.com for more information
1.Glycosaminoglycan (GAG)&Proteoglycans (PG) Amino polysaccharide is a straight polysaccharide chain constituted by repeated disaccharide units. GAG disaccharide units sulfate groups Distribution per unit Hyaluronan Glucuronic acid-N-acetyl 0 Connective tissue,skin, glucosamine cartilage,synovial fluid vitreous Chondroitin Glucuronic acid-N-acetyl 0.2-2.3 Cartilage,cornea,bone,skin, sulfate galactosamine arterial Dermatan Glucuronic acid or Aidoo 1.0-2.0 Skin,blood vessels,heart, sulfate uronic acid-N-acetyl valve 出到 galactosamine heparan Glucuronic acid or Aidoo 0.2-3.0 lung artery,and cell surface sulfate uronic acid-N-acetyl glucosamine Heparin Glucuronic acid or Aidoo 2.0-3.0 Lung,liver,skin,mast cells uronic acid-N-acetyl glucosamine This document is produced by trial version of Print2Flash.Visit www.printflash.com for more information