Developmental biology 用鹌鹑的AER取代无肢体鸡的AER 可以导致正常的肢体发育 Figure 18.19 The limbless embryo fails to form AER, and the defect appears to reside in the ectoderm. If wild-type quail ectoderm replaces the mutant chick ectoderm in the region that forms a forelimb, the wing will develop on that side of the embryo. No other limb forms.(After Carrington and Fallon, 1988; photograph courtesy of J. Fallon
Developmental Biology 用鹌鹑的AER取代无肢体鸡的AER 可以导致正常的肢体发育
De Hannis AER对P一D轴线影响的 分子基础是FGF因子 Add bad soluton 20 ou 学 NU bOUTH 尺emoe Figure 18.17 Ability of FGl2 to nplace apical ectodermal ndge in developing chick forelimb bud(A) When the AER is removed from stage 20 chick wing buds, only the humerus is able to form. (B) When a slow release gel bead soaked in saline solution 由hmhm由 bud continues to grow and to make th
Developmental Biology AER 对 P － D轴线影响的 分子基础是FGF因子
Der Progress zone(PZ)识别和决定肢体的P一D轴生长程度 证据 Progress z0ne是指AER内 保持了旺盛分裂 能力的间质细胞 区域。 (A) 不同时间离 开 progress zone 的细胞分化为不 同的软骨。证据 之一是,在不同 时间去除AER, 所形成的肢体骨 Figure 18 13 不同。 Dorsal view of chick skeletal pattern after removal of the entire AER from the right wing bud of embryos at various stages. The last photo()is of a normal wing skeleton (From Iten, 1982, courtesy of L Iten
Developmental Biology Progress Zone (PZ) 识别和决定肢体的P－D轴生长程度 证 据 一 Progress zone是指AER内 保持了旺盛分裂 能力的间质细胞 区域。 不同时间离 开progress zone 的细胞分化为不 同的软骨。证据 之一是，在不同 时间去除AER， 所形成的肢体骨 不同