Formation of biological amines amino acid decarboxyl.product examples of functions aspartic acid B alanine coenzyme A cysteine cysteamine coenzyme A dihydroxy- dopamine neuro-transmitter phenylalanine glutamic acid y aminobutyric acid neuro-transmitter histidine histamine mediator in allergic reactions lysine cadaverine corpse venom ornithine putrescine polyamine metabolism serine ethanolamine phospholipids threonine aminopropanol vitamine B12 tyrosine tyramine uterus contraction tryptophane tryptamine probably hormon action hydroxy- serotonine neuro-transmitter tryptophane
amino acid decarboxyl. product examples of functions aspartic acid ß alanine coenzyme A cysteine cysteamine coenzyme A dihydroxyphenylalanine dopamine neuro-transmitter glutamic acid g aminobutyric acid neuro-transmitter histidine histamine mediator in allergic reactions lysine cadaverine corpse venom ornithine putrescine polyamine metabolism serine ethanolamine phospholipids threonine aminopropanol vitamine B12 tyrosine tyramine uterus contraction tryptophane tryptamine probably hormon action hydroxytryptophane serotonine neuro-transmitter Formation of biological amines
Amino acid metabolism Decarboxylation Deamination Transamination Urea cycle ● Pyruvate group a Ketoglutarate group Succinyl-CoA group Oxaloacetate group Fumarate oxaloacetate group ● Alanine acetoacetate group Acetyl-CoA acetoacetate group
Amino acid metabolism • Decarboxylation √ • Deamination • Transamination • Urea cycle • Pyruvate group • a Ketoglutarate group • Succinyl-CoA group • Oxaloacetate group • Fumarate / oxaloacetate group • Alanine / acetoacetate group • Acetyl-CoA / acetoacetate group
amino acid deamination protein intra uptake cellular protein amino acids desamination a ketoacids NHa glucose amino citric acids acid nucleo- cycle tides metabolites CO2,H2O urea
amino acids protein uptake intra cellular protein a ketoacids NH4 + citric acid cycle amino acids, nucleotides CO2, H2O urea metabolites glucose desamination amino acid deamination
Deamination of amino acids 1.oxidative deamination NADP NAD NADPH NADH COOH COOH HN=0 H30 COOH C=0 NHg Glutamat NAD H2O NH3 2-Oxoglutarat NADH
Deamination of amino acids 1. oxidative deamination
2.deamination by B elimination (Ser,Thr,Cys) COOH COOH PLPEN-C-H CH2 H20 OH serine PLP COOH COOH HN■C H20 COOH NHg CH PLP pyridoxalphosphate pyruvate
2. deamination by ß elimination (Ser, Thr, Cys) PLP = pyridoxalphosphate serine pyruvate