Tumor Antigen ype of antigen Examples of human tumor antigens Products of oncogenes, Oncogenes: Ras mutations (10% of human carcinomas), p210 tumor suppressor genes product of Bcr/Abl rearrangements(CML), overexpressed Her 2/neu(breast and other carcinomas Tumor supressor genes: mutated p53(present in -50% of human tumors) Mutants of cellular genes not p91A mutation in mutagenized murine mastocytoma; various nvolved in tumorigenesis mutated proteins in melanomas recognized by CTLs Products of genes that are Cancer/testis antigens expressed in melanomas and many silent in most normal tissues carcinomas; normally expressed mainly in the testis and placenta Products of overexpressed Tyrosinase, gp100, MART in melanomas(normally expressed in genes melanocytes) Products of oncogenic Papillomavirus E6 and E7 proteins(cervical carcinomas) viruses EBNA-1 protein of EBV(EBV-associated lymphomas nasopharyngeal carcinoma) SV40 T antigen(SV40-induced rodent tumors) Oncofetal antigens Carcinoembryonic antigen(CEA) on many tumors, also expressed in liver and other tissues during inflammation Alpha-fetoprotein(AFP) Glycolipids and glycoproteins GM2 GD2 on melanomas Differentiation antigens Prostate-spec ific antigen normally present in tissue of ongin Markers of lymphocytes: CD10, CD20, Ig idiotypes on B cells
DEPARTMENT OF IMMUNOLOGY Tumor Antigen Type of antigen Examples of human tumor antigens Products of oncogenes, tumor suppressor genes Oncogenes: Ras mutations (∼10% of human carcinomas), p210 product of Bcr/Abl rearrangements (CML), overexpressed Her- 2/neu (breast and other carcinomas) Tumor supressor genes: mutated p53 (present in ∼50% of human tumors) Mutants of cellular genes not involved in tumorigenesis p91A mutation in mutagenized murine mastocytoma; various mutated proteins in melanomas recognized by CTLs Products of genes that are silent in most normal tissues Cancer/testis antigens expressed in melanomas and many carcinomas; normally expressed mainly in the testis and placenta Products of overexpressed genes Tyrosinase, gp100, MART in melanomas (normally expressed in melanocytes) Products of oncogenic viruses Papillomavirus E6 and E7 proteins (cervical carcinomas) EBNA-1 protein of EBV (EBV-associated lymphomas, nasopharyngeal carcinoma) SV40 T antigen (SV40-induced rodent tumors) Oncofetal antigens Carcinoembryonic antigen (CEA) on many tumors, also expressed in liver and other tissues during inflammation Alpha-fetoprotein (AFP) Glycolipids and glycoproteins GM2 GD2 on melanomas Differentiation antigens normally present in tissue of origin Prostate-specific antigen Markers of lymphocytes: CD10, CD20, Ig idiotypes on B cells
Content 1. General Features 2. Tumor antigen 3. Immune Responses 4. Evasion of Immune Responses 5. Immunotherapy
DEPARTMENT OF IMMUNOLOGY Content 1. General Features 2. Tumor antigen 3. Immune Responses 4. Evasion of Immune Responses 5. Immunotherapy