General Features Tumor express antigens that are recognized as foreign by the immune system of the tumor-bearing host Immune responses frequently fail to prevent the growth of tumors . The immune system can be activated external stimuli to effectively kill tumor cells and eradicate tumors
DEPARTMENT OF IMMUNOLOGY General Features ❖ Tumor express antigens that are recognized as foreign by the immune system of the tumor-bearing host. ❖ Immune responses frequently fail to prevent the growth of tumors. ❖ The immune system can be activated external stimuli to effectively kill tumor cells and eradicate tumors
Tumor Antigen Mouse with chemical carcinogen induced tumor Resect tumor Isolate CD8+ T cells Transplant tumor cells Transplant tumor cells Adoptively transfer into original Tumor into syngeneic mouse T cells into recipient tumor-bearing mouse cells of tumor transplant Eradication No tumor growth Tumor growth of tumor
DEPARTMENT OF IMMUNOLOGY Tumor Antigen
Immune responses frequently fail to prevent the growth of tumors s First, tumor cells are derived from host cells Second, the rapid growth and spread of tumors Third, specialized mechanisms for evading host Immune responses
DEPARTMENT OF IMMUNOLOGY ❖ Immune responses frequently fail to prevent the growth of tumors ❖ First, tumor cells are derived from host cells. ❖ Second, the rapid growth and spread of tumors ❖ Third, specialized mechanisms for evading host immune responses
Content 1. General Features 2. Tumor antigen 3. Immune Responses 4. Evasion of Immune Responses 5. Immunotherapy
DEPARTMENT OF IMMUNOLOGY Content 1. General Features 2. Tumor antigen 3. Immune Responses 4. Evasion of Immune Responses 5. Immunotherapy
Tumor Antigen The earliest classification . Tumor-specific antigen Tumor-associated antigen
DEPARTMENT OF IMMUNOLOGY Tumor Antigen The earliest classification: ❖ Tumor-specific antigen ❖ Tumor-associated antigen