B ☐快代谢型 20叶 国慢代谢型 例数（个） 10以 5 30 6090 120 150180 210 240 270 异烟井t⅓min
Shanghai Jiao Tong University
上游充通大￥ Side effects of isoniazid Shanghai Jiao Tong University ①Peripheral neuropathy(外周神经炎)；CNS excitement INH→Vit Bel→GABA↓→CNS excitement seen in slow acetylation,Vit B6 prevention ②hepatic injury acetylated products-monoacetyl isoniazid (liver toxic) seen in rapid acetylation,hepatic function test needed
Shanghai Jiao Tong University Side effects of isoniazid ① Peripheral neuropathy（外周神经炎）；CNS excitement INH → Vit B6↓→ GABA↓→ CNS excitement seen in slow acetylation，Vit B6 prevention ② hepatic injury acetylated products—monoacetyl isoniazid（liver toxic） seen in rapid acetylation，hepatic function test needed
浒充通大学 rifampicin(利福平) Shanghai Jiao Tong University 二= HO, HO H OH NH 三 OH 三
Shanghai Jiao Tong University rifampicin（利福平）
上游充通大￥ Shanghai Jiao Tong University RIFAMPIN FOR INJECTION,USP 600mg FOR IV INFUSION ONLY Rx ONLY. O 2002 GSM
Shanghai Jiao Tong University
上游充通大￥ discovery of rifampicin 后 Shanghai Jiao Tong University 1957,soil from pine wood,French Riviera Piero Sensi,Italy,found new bacterium Researchers fond of French crime story Rififi (about a jewel heist and rival gangs Named“Rifamycins” 1959,rifampicin discovered
Shanghai Jiao Tong University discovery of rifampicin 1957，soil from pine wood, French Riviera Piero Sensi, Italy, found new bacterium Researchers fond of French crime story Rififi (about a jewel heist and rival gangs ) Named “Rifamycins” 1959, rifampicin discovered