上游充通大￥ Therapeutic history 后 Shanghai Jiao Tong University Before 1930's:I nutrition therapy:rest, nutrition,fresh air,cure rate 25% 1930~1950's:nutrition therapy physical therapy (artificial pneumothorax),cure rate 40% Drugs difficulty in entering the cells 1950's:streptomycin,isoniazid,rifampicin; cure rate >90% 21 century:multidrug resistance,TB incidence↑
Shanghai Jiao Tong University Therapeutic history Before 1930’s：nutrition therapy：rest, nutrition, fresh air, cure rate 25% 1930～1950’s： nutrition therapy + physical therapy (artificial pneumothorax) , cure rate 40% Drugs difficulty in entering the cells 1950’s：streptomycin, isoniazid, rifampicin； cure rate >90% 21 century：multidrug resistance, TB incidence ↑
上浒克通大睾 The evolu Shanghai Jiao Tong University The Nobel Prize in Physiology or Medicine 1952 "for his discovery of streptomycin,the first antibiotic effective The discovery of the against tuberculosis" antitubercular activity of aminoglycoside antibiotics streptomycin by Waksman et al in 1944 ushered in the modern era of tuberculosis treatment. Selman Abraham Waksman
Shanghai Jiao Tong University The discovery of the antitubercular activity of aminoglycoside antibiotics streptomycin by Waksman et al in 1944 ushered in the modern era of tuberculosis treatment. The evolution of antitubercular agents
上游充通大￥ Shanghai Jiao Tong University 1952,p-amino-salicylic acid(PAS) 1952,isoniazid Ethambutol 1959,rifampicin
Shanghai Jiao Tong University 1952, p-amino-salicylic acid(PAS) 1952, isoniazid Ethambutol 1959, rifampicin
上降文 Shangh 人/10万 20 结核 脑血管疾病 01 0 癌 10 心血管疾病 0 10 11D 1920 135 设0 1050 100 1970 1280 年 本世纪三大花因及结核的死亡率变化
Shanghai Jiao Tong University
上泽充通大睾 Anti-TB drugs 后 Shanghai Jiao Tong University First-line drugs: Isoniazid(异烟肼) Rifampicin(利福平) Ethambutol(乙胺丁醇) Pyrazinamide(吡嗪酰胺) Streptomycin(链霉素) Second-line drugs: Ethionamide(乙硫异烟胺) Para-aminosalicylic acid(对氨水杨酸) rifapentine(利福喷丁) sparfloxaxcin(司帕沙星)
Shanghai Jiao Tong University Anti-TB drugs First-line drugs: Isoniazid（异烟肼） Rifampicin（利福平） Ethambutol（乙胺丁醇） Pyrazinamide（吡嗪酰胺） Streptomycin（链霉素） Second-line drugs: Ethionamide（乙硫异烟胺） Para-aminosalicylic acid（对氨水杨酸） rifapentine（利福喷丁） sparfloxaxcin（司帕沙星）