Pol lll promoter may be 20.5 RNA polymerase III downstream of the startpoint uses both downstream Startpoint and upstream promoters Promoter Transcribed region 入NNNN入入八NN Figure 20.5 Deletion analysis shows that the RNA promoter for 5S RNA Deletion that removes sequences upstream of genes is internal; prom oter allows transcription to init ate from initiation occurs a position corresponding to usual startpoint fixed distance (~55 bp) NNN八N八NNN upstream of the promoter. RNA 情華大当
Figure 20.5 Deletion analysis shows that the promoter for 5S RNA genes is internal; initiation occurs a fixed distance (~55 bp) upstream of the promoter. 20.5 RNA polymerase III uses both downstream and upstream promoters
20.5 RNA polymerase III uses both downstream and upstream promoters Startpoint 八N八NN入NS bOx A box C 八haan box A box B 八八VU20202020风N八 Oct PSE TATA Figure 20.6 Promoters for RNA polymerase IlI may consist of bipartite sequences downstream of the startpoint,with boxA separated from either boxC or boxB.Or they may consist of separated sequences upstream of the startpoint 清菜大当 (Oct,PSE,TATA)
Figure 20.6 Promoters for RNA polymerase III may consist of bipartite sequences downstream of the startpoint, with boxA separated from either boxC or boxB. Or they may consist of separated sequences upstream of the startpoint (Oct, PSE, TATA). 20.5 RNA polymerase III uses both downstream and upstream promoters
20.5 RNA polymerase III uses both downstream and upstream promoters Type 1 internal promoters Type 2 internal promoters Starpoint Startpoint wwwXwAmY Figure 20.7 TFIIC TFIC Initiation via the 八八入八八N入入入入八八八八八NN入N internal pol III TFIIC promoters involves 入八VV0 the assembly factors TFIB TFIIIB TFIIIA and TFIIIC, Miana八NN八N the initiation factor TFIIIB,and RNA N入入入入八八八入N八八N入八八入入M八N Polll polymerase III. N入入NN八八N八NNNN入入八八N 情菜大当
Figure 20.7 Initiation via the internal pol III promoters involves the assembly factors TFIIIA and TFIIIC, the initiation factor TFIIIB, and RNA polymerase III. 20.5 RNA polymerase III uses both downstream and upstream promoters
20.6 The startpoint for RNA polymerase TATA box is a conserved A.T-rich septamer found about 25 bp before the startpoint of each eukaryotic RNA polymerase Il transcription unit;may be involved in positioning the enzyme for correct initiation. 清菜大兰
TATA box is a conserved A·T-rich septamer found about 25 bp before the startpoint of each eukaryotic RNA polymerase II transcription unit; may be involved in positioning the enzyme for correct initiation. 20.6 The startpoint for RNA polymerase II
Pol lll promoters 20.7 TBP is a TBP TF universal factor TFIlIC 八NN八八NN RNA polymerase lll Figure 20.8 Pol I promoters RNA SL RNA polymerase I polymerases are 八VUX positioned at all UBF1 Pol ll promoters promoters by a TBP factor that contains TBP. 情華大当 RNA polymerase
Figure 20.8 RNA polymerases are positioned at all promoters by a factor that contains TBP. 20.7 TBP is a universal factor