PATHOGENESIS Inside the host phagocytized but able to survive- production of SUPEROXIDE DISMUTASE Which blocks the formation of toxic 2 radicals carried to lymph nodes, blood stream, reticuloendothelial system like liver, spleen, and bone marrow PMNs degenerate and release intracellular organisms gain endocytosed by macrophages and monocytes
PATHOGENESIS Inside the host phagocytized but able to survive -- production of SUPEROXIDE DISMUTASE which blocks the formation of toxic O2 radicals carried to lymph nodes, blood stream, reticuloendothelial system like liver, spleen, and bone marrow. PMNs degenerate and release intracellular organisms Again endocytosed by macrophages and monocytes
Epidemiology Brucellosis - ZOONOSIS Human infection - direct or indirect contact with infected animal tissue Direct animal contact Contact with animal products Ingestion of unpasteurized dairy products Through abrasions or cuts, the conjunctiva, or the gastrointestinal tract
Brucellosis -- ZOONOSIS Human infection -- direct or indirect contact with infected animal tissue. ◦ Direct animal contact ◦ Contact with animal products ◦ Ingestion of unpasterized dairy products Through abrasions or cuts , the conjunctiva, or the gastrointestinal tract
People at risk Mainly Farmers, abattoir workers, butchers, veterinarians are at risk >infection can occur through contamination of conjunctiva and skin with discharges Main source of infection to general population is by dairy products prepared from infected milk. Neonatal infection can be acquired by the transplacental route, during delivery or via the ingestion of contaminated breast milk
Mainly Farmers, abattoir workers, butchers, veterinarians are at risk. infection can occur through contamination of conjunctiva and skin with discharges Main source of infection to general population is by dairy products prepared from infected milk. Neonatal infection can be acquired by the transplacental route, during delivery or via the ingestion of contaminated breast milk